ArticleBehavior genetics2025
Assessing genetic conservation of human sociability-linked genes in C. elegans.
Article in Behavior genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Peptone-free nematode growth medium improves culture stability and physiological resilience in Caenorhabditis elegans.Biogerontology · 2026Article
- Neuromodulation of swarming behavior inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neuromodulation of Swarming Behavior inbioRxiv : the preprint server for biology · 2025Article
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Authors and funding
2 authors.
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Abstract
Social behavior is a common though variable trait across animal species. How much of the variation in social behavior is due to biological common mechanisms across animal species is unknown. In this study we examined to what extent human genetic variation in sociability is affected by pathways shared with Caenorhabditis elegans and whether any conserved sociability-linked genes show enhanced levels of essential functions and interactivity. We found inconsistent evidence of increased conservation with more thorough analyses resulting in no evidence of increased conservation of human sociability-linked genes. Conserved genes were highly interactive compared to nonconserved and random genes, while only a limited number of genetic interactions were found to be conserved. No evidence was found for enrichment of social phenotypes in C. elegans orthologs of human sociability-linked genes while evidence for associations with essential functions were limited. The activin A receptor type 2A (ACVR2A) gene appears to play a role in social behavior in both humans and C. elegans, making it an interesting gene for further study.
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