ReviewVirchows Archiv : an international journal of pathology2025
Sinonasal EWSR1::POU2AF3 sarcoma: a case report and literature review.
Review in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Sinonasal POU2AF3 (COLCA2)-rearranged carcinomas: a study of 11 aggressive tumors with findings supporting classification as solid adenoid cystic carcinoma.Virchows Archiv : an international journal of pathology · 2026Article
- EWSR1::BEND2 fusion sarcoma of the urinary bladder - a case report and review of literature.Diagnostic pathology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
We present the clinicopathologic and molecular characteristics of a rare sinonasal sarcoma with undifferentiated round cell and spindle morphology, defined by the EWSR1::POU2AF3 fusion. A 62-year-old male presented with nasal congestion. A polypoid lesion excised from the sinonasal cavity was initially diagnosed as 'glomangiopericytoma' at an external center, but recurred and was referred to our clinic four years later. Histopathological evaluation of primary and recurrent tumors showed pleomorphic spindle and round cell morphology with prominent nucleoli and thin-walled hemangiopericytomatous vessels. CD99 (MIC2) and CD117 (CKIT) were diffuse positivite while ß-catenin showed cytoplasmic/membranous expression. Pancytokeratin and EMA were focally positive. NKX2.2, DUX4, ETV4, BCOR, CCNB3, SS18-SSX, STAT6, CD34, and others were all negative. Next generation sequencing confirmed EWSR1::POU2AF3 fusion. This case exemplifies a rare, aggressive sinonasal sarcoma with EWSR1::POU2AF3 fusion, emphasizing its distinct morphology and challenging behaviour.
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Registered trials
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