ArticleNeuroradiology2025
Enlarged perivascular spaces as vascular health indicators: correlations with clinical and imaging data in young and middle-age stroke patients.
Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Perivascular spaces as MRI markers associated with radiation necrosis in brain metastases patients: an exploratory study.Neuroradiology · 2026Article
- Comparison of T1w, T2w, and T1w/T2w MRI methods for perivascular space quantification.Neuroradiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo understand the role of enlarged Perivascular Spaces (PVSs) in a population with young middle age stroke and to identify predictors of PVSs enlargment using clinical and imaging data. MATERIALS/
methodsRetrospective revision of demographics, clinical and MRI data, of 163 patients, with MRI confirmed stroke. Ischemic area and WMH were semi-automatically segmented on DWI images and FLAIR images. Severity of PVS was evaluated on T2-weighted images according to the Potter scale. To identify potential predictors of the extent of PVSs, an exploratory backward stepwise ordinal regression model was developed, including all measured variables.
resultsWith the extent of PVSs at Basal Ganglia as the dependent variable, the logarithm of WMH demonstrated a significant positive association with the outcome. ESUS exhibited a positive relationship, underscoring its potential role as a predictor of the outcome. In PVSs in Mid Brain, dyslipidemia displayed a significant negative effect, signifying a reduced likelihood of the outcome in its presence. Hypertension emerged as a statistically significant and notably positive predictor of PVSs.
conclusionSignificant associations between PVSs, WMH volume, and vascular features suggest their potential as vascular health indicators. These findings underscore the potentiality of PVSs as a biomarker for further investigation in stroke research. However, given the cross-sectional nature of our data, the relationship between PVS alterations and stroke requires further longitudinal studies to clarify their role and temporal association and eventually refining diagnostic and therapeutic approaches and mitigating stroke risks for younger stroke populations.
Indexed as
Identifiers
39982491What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.