Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025
Clinical characteristics of optic neuritis following COVID-19 during Omicron outbreak in China.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the clinical characteristics of early-onset optic neuritis (ON) following the corona virus disease 2019 (COVID-19) Omicron variant and explore the possible pathophysiological mechanisms.
methodsThis was a retrospective, observational study. All enrolled patients with ON following the COVID-19 Omicron variant were followed for at least 6 weeks to observe their clinical characteristics and prognostic factors and to analyze the factors influencing earlier or later occurrence of ON following the COVID-19 Omicron variant.
resultsA total of 47 eyes from 47 patients (22 males [46.8%] and 25 females [53.2%]) were enrolled in this study and divided into late- and early-onset groups. Compared to the late-onset group, the early-onset group had a higher dual-seronegative antibody status (21.43% vs. 63.16%, P = 0.004) and a higher CD8 + /lymphocyte percentage (23.3% [20.1%, 28.3%] vs. 31.0% [29.8%, 34.2%], P = 0.008). Furthermore, Pearson's partial correlation analysis showed that dual-seronegative antibody status (adjusted r = 0.800, adjusted P = 0.001) and CD8 + /lymphocyte percentage (adjusted r = 0.747, adjusted P = 0.002) were independently associated with early-onset ON following the COVID-19 Omicron variant. Further partial correlation analysis also showed that a swollen optic disc (r = -0.347, P = 0.035) was the only factor independently associated with final best-corrected visual acuity (BCVA).
conclusionsEarlier onset of ON following COVID-19 Omicron variant indicated a higher CD8 + /lymphocyte percentage in the serum and a greater possibility of dual-seronegative antibody status. Whether ON following the COVID-19 Omicron variant occurred earlier or later did not independently affect final BCVA, and the only independent factor predicting better final BCVA was a swollen optic disc.
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