Evidence map›Paper›PMID 39982363›Full record

ArticlePathophysiology : the official journal of the International Society for Pathophysiology2025

Overweight-Related Hypertension in Middle-Aged Men Is Linked to Elevated Leptin, TNF-α, IL-6, Cholesterol, and Reduced Testosterone.

Shalan Alaamri, Abdulhalim S Serafi, Zahir Hussain, Shouq K Bafail, Mohammed A Bafail, Lusine Demirkhanyan, Christopher S Gondi, Sumera Sohail

Abstract read
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In one paragraph

Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shalan AlaamriDepartment of Medicine, College of Medicine, University of Jeddah, Jeddah 21589, Saudi Arabia.
Abdulhalim S SerafiDepartment of Physiology, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Zahir HussainDepartment of Physiology, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0003-4739-1865
Shouq K BafailDepartment of Biology, College of Sciences, Umm Al-Qura University, Aljamoum 22254, Saudi Arabia.
Mohammed A BafailDepartment of Physiology, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-8702-2258
Lusine DemirkhanyanDepartment of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, IL 61605, USA.ORCID 0000-0002-3535-7996
Christopher S GondiDepartment of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, IL 61605, USA.
Sumera SohailDepartment of Physiology, University of Karachi, Karachi 75270, Pakistan.

Funding

This work was supported financially by the Deanship of Scientific Research at Umm Al-Qura University, Makkah, Saudi Arabia. 19-MED-1-01-0022
6 · The paper itself

Abstract

BACKGROUND/

objectivesOne of the major causes of hypertension (HT) is the transition of normal weight (NW) status to overweight (OW) status and obesity in a population, which leads to cardiovascular disease (CVD) and other disorders. A variety of factors/variables are involved in the development of HT and OW-related hypertension (OHT). However, we planned to investigate the pathophysiological role of serum leptin (Lep), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), total cholesterol (TC) and serum testosterone (ST) in OHT in middle-aged men.

methodsWe consulted three groups of middle-aged men (age: 51-60 years)-an HT group (n: 97, high normal weight (HNW), body mass index (BMI): 23-24.9 kg/m

resultsSignificant variations were obtained for the comparisons of TNF-α, Lep, ST and TC for the patient groups. OHT vs. NC showed a significant difference for ST. OHT vs. NC and OHT vs. HT had significant variations for IL-6. Significant changes were obtained for the serum levels of TNF-α, Lep, IL-6, ST and TC among groups. Significant and positive linear associations were obtained for TNF-α, Lep, TC and IL-6. Significant and negative linear associations were found for ST plotted against Lep, TNF-α and IL-6.

conclusionsThe current report provides pathophysiological evidence of the interactive role of serum Lep, TNF-α, ST, TC and IL-6 in middle-aged men with HT and OHT. We suggest that the changes we noted in the present study would be helpful for further BMI-based studies in various subcategories of NW, OW and obese subjects with/without HT.

Indexed as

hypertensionIL-6middle-aged menoverweight-related hypertensionpathophysiologyserum leptintestosteroneTNF-αtotal cholesterol

Identifiers

PMID39982363
PMCPMC11843874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.