Evidence map›Paper›PMID 39982254›Full record

GuidelineJournal of lower genital tract disease2025

Self-Collected Vaginal Specimens for HPV Testing: Recommendations From the Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee.

Nicolas Wentzensen, L Stewart Massad, Megan A Clarke, Francisco Garcia, Robert Smith, Jeanne Murphy, Richard Guido, Ana Reyes, Sarah Phillips, Nancy Berman and 4 more

Abstract readPractice Guideline
In one paragraph

Guideline in Journal of lower genital tract disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  6. Development and validation of the gynecologic examination anxiety scale (GEAS): A 20-item patient-reported measure.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  7. Review
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  9. Female allogeneic hematopoietic cell transplant survivors' perspectives on cervical cancer screening: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicolas WentzensenDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
L Stewart MassadDivision of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO.
Megan A ClarkeDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
Francisco GarciaUniversity of Arizona, Tucson, AZ.
Robert SmithAmerican Cancer Society, Atlanta, GA.
Jeanne MurphyJohns Hopkins University School of Medicine, Baltimore, MD.
Richard GuidoDepartment of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA.
Ana ReyesCervivor, Inc., Upper Marlboro, MD.
Sarah PhillipsDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
Nancy BermanMillennium Affiliated Physicians, Division of Michigan Healthcare Professionals, Farmington Hills, MI.
Jeffrey QuinlanDepartment of Family Medicine, Carver College of Medicine, University of Iowa Healthcare, Iowa City, IA.
Eileen LindTeam Maureen, Falmouth, MA.
Rebecca B PerkinsDepartment of Obstetrics and Gynecology, Tufts University and Tufts Medical Center, Boston, MA.
Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of self-collected vaginal specimens for human papillomavirus (HPV) testing in health care settings.

methodsA comprehensive literature search was performed, external systematic reviews were evaluated, and HPV genotype agreement between self-collected vaginal and clinician-collected cervical specimens was summarized. Recommendations considered available data, public comments, and expert consensus. Recommendations were ratified through a vote by the Consensus Stakeholder Group.

resultsClinician-collected cervical specimens are preferred and self-collected vaginal specimens are acceptable for primary HPV screening of asymptomatic average-risk individuals. Repeat testing in 3 years is recommended following HPV-negative screens using self-collected vaginal specimens. Colposcopy with collection of cytology and biopsies is recommended following positive tests for HPV types 16 and 18. Clinician-collected cytology or dual stain for triage testing is recommended following positive tests for HPV 45, 33/58, 31, 52, 35/39/68, or 51 or for pooled HPV other types but negative for HPV 16 or 18. Repeat HPV testing in 1 year is recommended following a positive test for HPV types 56/59/66 and no other carcinogenic types. Minimal data exist on use of self-collected vaginal specimens for surveillance following abnormal screening test results, colposcopy or treatment, and therefore, clinician-collected cervical specimens are preferred.

conclusionsHuman papillomavirus testing of self-collected vaginal specimens expands cervical cancer screening options and has potential to increase access for currently underscreened individuals. Laboratory and clinical workflows will need to be modified to ensure adequate specimen processing and follow-up.

Indexed as

Early Detection of CancerPapillomaviridaePapillomavirus InfectionsSpecimen HandlingUterine Cervical NeoplasmsVaginaColposcopyFemaleHumans

Identifiers

PMID39982254
PMCPMC11939108

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.