Evidence map›Paper›PMID 39982068›Full record

ArticlemBio2025

Non-disruptive matrix turnover is a conserved feature of biofilm aggregate growth in paradigm pathogenic species.

Courtney Reichhardt, Michael L Matwichuk, Lincoln T Lewerke, Holly M Jacobs, Jing Yan, Matthew R Parsek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Courtney ReichhardtDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-1022-5110
Michael L MatwichukDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Lincoln T LewerkeDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Holly M JacobsDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Jing YanDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2932-7966

Funding

The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
The biofilm matrix of P. aeruginosaR01AI143916 · NIAID · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL, PARSEK, MATTHEW R. · 2019 to 2023
$2.9M
Tracking single-cell gene expression heterogeneity and its consequences in bacterial biofilmsDP2GM146253 · NIGMS · YALE UNIVERSITY · PI YAN, JING · 2021 to 2024
$2.5M
Pseudomonas biofilms and immunityR01AI097511 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2013 to 2017
$1.9M
Functionality of CdrA and its processed forms within Pseudomonas aeruginosa biofilmsK99GM134121 · NIGMS · UNIVERSITY OF WASHINGTON · PI REICHHARDT, COURTNEY · 2019 to 2020
$178k
American Heart Association (AHA) 18PRE33960065Cystic Fibrosis Foundation (CFF) REICHH19F5HHS | National Institutes of Health (NIH) 5K99GM134121-02HHS | National Institutes of Health (NIH) DP2GM146253HHS | National Institutes of Health (NIH) R01AI34895, R01AI077628, R01AI097511NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI097511NIAID NIH HHS R01 AI143916NIGMS NIH HHS DP2 GM146253NIGMS NIH HHS K99 GM134121
6 · The paper itself

Abstract

Bacteria form multicellular aggregates called biofilms. A crucial component of these aggregates is a protective matrix that holds the community together. Biofilm matrix composition varies depending upon bacterial species but typically includes exopolysaccharides (EPS), proteins, and extracellular DNA. IMPORTANCE: Here, we show that, to accommodate growing cellular biomass, newly produced Psl is deposited over existing Psl at the periphery of biofilm aggregates. We demonstrated that

Indexed as

BiofilmsExtracellular Polymeric Substance MatrixPolysaccharides, BacterialPseudomonas aeruginosaBacterial ProteinsBacterial ProteinsPolysaccharides, BacterialbiofilmsCdrAexopolysaccharidesPseudomonas aeruginosaPslVibrio cholerae

Identifiers

PMID39982068
PMCPMC11898600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.