Evidence map›Paper›PMID 39982063›Full record

Trial reportmSystems2025

Gut microbiota development in very preterm infants following fortification of human milk.

Lin Yang, Yan Hui, Per Torp Sangild, Witold Piotr Kot, Lise Aunsholt, Gitte Zachariassen, Ping-Ping Jiang, Dennis Sandris Nielsen

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03537365 (Bovine Colostrum to Fortify Human Milk for Preterm Infants A Randomized, Controlled Pilot Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03537365 nacompletednot on this map

Bovine Colostrum to Fortify Human Milk for Preterm Infants A Randomized, Controlled Pilot Trial

TypeinterventionalSponsorPer Torp SangildRan2017 to 2022Enrolled252ConditionsGrowth, Necrotizing Enterocolitis, Late-Onset Sepsis, Feeding IntoleranceArmsBovine Colostrum (BC) / intervention group, FM85 / control group
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lin YangSection for Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Yan HuiDepartment of Food Science, University of Copenhagen, Frederiksberg, Denmark.
Per Torp SangildSection for Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Witold Piotr KotDepartment of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg, Denmark.
Lise AunsholtSection for Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Gitte ZachariassenDepartment of Neonatology, Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Ping-Ping JiangSection for Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0002-7393-9719
Dennis Sandris NielsenDepartment of Food Science, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0001-8121-1114

Funding

China Scholarship Council 202006780012Innovation Fund Denmark NEOCOL 6150-00004B
6 · The paper itself

Abstract

Very preterm infants (VPIs) are born with an immature gut and predisposed to gut microbiota dysbiosis-related diseases, for example, necrotizing enterocolitis. Although fortification of human milk is required for these infants, the optimal fortifier remains uncertain. Bovine colostrum (BC), rich in protein and bioactive components, could serve as an alternative to conventional fortifiers (CF). The gut microbiota (GM) of 225 VPIs fed human milk fortified with either BC or CF (FortiColos study, NCT03537365) was profiled by 16S rRNA gene amplicon sequencing of fecal samples collected before, and after 1 and 2 weeks of fortification. Birth mode exhibited transient effects on the microbial community structure shortly after birth, with cesarean section-born VPIs dominated by

Indexed as

Food, FortifiedGastrointestinal MicrobiomeInfant, Extremely PrematureMilk, HumanAnimalsCattleColostrumFecesFemaleHumansInfant, NewbornInfant, PrematureMaleRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbirth modebovine colostrumenteral feedgut microbiotahuman milknutrient fortifierpreterm infant

Identifiers

PMID39982063
PMCPMC11915873

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.