Evidence map›Paper›PMID 39981937›Full record

ArticleEcology letters2025

Warming During Different Life Stages has Distinct Impacts on Host Resistance Ecology and Evolution.

Jingdi Li, Cameron A Smith, Jinlin Chen, Kieran A Bates, Kayla C King

Abstract read
In one paragraph

Article in Ecology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingdi LiDepartment of Biology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-5426-590X
Cameron A SmithDepartment of Biology, University of Oxford, Oxford, UK.
Jinlin ChenDepartment of Biology, University of Oxford, Oxford, UK.
Kieran A BatesBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Kayla C KingDepartment of Biology, University of Oxford, Oxford, UK.

Funding

Canada Excellence Research Chairs, Government of CanadaEuropean Research Council COEVPRO 80224Natural Environment Research Council NE/X000540/1Pembroke College, University of Oxford Graduate Scholarship
6 · The paper itself

Abstract

Climate change is increasing extreme heating events and the potential for disease outbreaks. Whether hosts can adapt to infection with rising temperatures is important for forecasting species persistence. We tested whether warming-at different host life stages-affects the ecological and evolutionary dynamics of resistance in Caenorhabditis elegans infected by a wild bacterial pathogen. We competed resistant and susceptible genotypes across 10 passages and tracked the spread of resistance in the population. Infection and prolonged warming strongly selected for the resistant genotype. Warming during host development induced plastic defences against infection, reducing the selective pressure for costly genetic-based resistance. Resistance was lost under ambient temperatures and periodic warming. Selection for resistance was likely weakened at ambient temperatures by the dilution effect, whereby the resistant genotype reduced pathogen transmission. Evolutionary dynamics of resistance depend on the balance among pathogen virulence, costs of genetic-based resistance, the dilution effect and plastic defences induced by temperature stress.

Indexed as

Biological EvolutionCaenorhabditis elegansAnimalsClimate ChangeGenotypeHost-Pathogen InteractionsHot TemperatureLife Cycle StagesTemperatureC. eleganshost–pathogen interactionsinfectionlife stagesresistance evolutionwarming

Identifiers

PMID39981937
PMCPMC11843851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.