Evidence map›Paper›PMID 39981895›Full record

ArticleMolecular medicine reports2025

Mechanism of β‑sitosterol in treating keloids: Network pharmacology, molecular docking and experimental verification.

Pingping Huo, Zhouna Li, Shan Jin, Sujie Wang, Yinli Luo, Lianhua Zhu, Zhehu Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pingping HuoKeloid Research Center, Department of Dermatology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
Zhouna LiDepartment of Medical Cosmetology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
Shan JinKeloid Research Center, Department of Dermatology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
Sujie WangKeloid Research Center, Department of Dermatology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
Yinli LuoKeloid Research Center, Department of Dermatology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.
Lianhua ZhuDepartment of Medicine, Yanbian University Medical College, Yanji, Jilin 133000, P.R. China.
Zhehu JinKeloid Research Center, Department of Dermatology, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β‑sitosterol (SIT) has anti‑inflammatory, anti‑tumor and anti‑fibrotic effects. However, the precise mechanisms underlying its efficacy in keloid treatment remain elusive. The present study aimed to elucidate the therapeutic effect of SIT on keloids. The active components of

Indexed as

KeloidSitosterolsAnimalsCell MovementCell ProliferationCell SurvivalDisease Models, AnimalEpithelial-Mesenchymal TransitionHumansMaleMiceMice, NudeMolecular Docking SimulationNetwork PharmacologyPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktgamma-sitosterolPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSitosterolskeloidmolecular dockingnetwork pharmacologyPTENβ‑sitosterol

Identifiers

PMID39981895
PMCPMC11868730

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.