Evidence map›Paper›PMID 39981893›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Base-Promoted Homolytic Aromatic Substitution (BHAS) Reactions and Hydrodehalogenations Driven by Green Light and an Iron(III)-NHC Photoredox Catalyst.

Lisa H M de Groot, Clara García-Mateos, Catherine E Johnson, Valtýr Freyr Hlynsson, Alpesh K Sharma, Reiner Lomoth, Kenneth Wärnmark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lisa H M de GrootCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, SE-22100, Lund, Sweden.ORCID https://orcid.org/0000-0001-6148-2259
Clara García-MateosCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, SE-22100, Lund, Sweden.ORCID https://orcid.org/0000-0003-3388-1281
Catherine E JohnsonDepartment of Chemistry - Ångström Laboratory, Uppsala University, SE-75120, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-9975-6577
Valtýr Freyr HlynssonCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, SE-22100, Lund, Sweden.ORCID https://orcid.org/0009-0002-2972-5155
Alpesh K SharmaCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, SE-22100, Lund, Sweden.ORCID https://orcid.org/0000-0001-5950-4818
Reiner LomothDepartment of Chemistry - Ångström Laboratory, Uppsala University, SE-75120, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-2246-1863
Kenneth WärnmarkCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, SE-22100, Lund, Sweden.ORCID https://orcid.org/0000-0002-9022-3165

Funding

Energimyndigheten P48747-1Knut and Alice Wallenberg Foundation KAW, 2018.0074LMK FoundationSten K Johnsons stiftelseStiftelsen för Miljöstrategisk Forskning SSF, EM16-0067)Vetenskapsrådet VR, 2020-03207Vetenskapsrådet VR, 2020-05058Wallenberg Initiative Materials Science for Sustainability (WISE))
6 · The paper itself

Abstract

An Fe(III)-NHC complex has been employed for the green light driven catalysis of base-promoted homolytic aromatic substitution (BHAS) reactions. Tributylamine was used as a sacrificial electron donor, together with potassium carbonate as base in dimethyl sulfoxide as solvent. In contrast to previously studied photocatalysts, the excited Fe(III)-NHC complex is not reducing the arylhalide substrates. Instead, the latter are activated by α-aminoalkyl radicals formed upon reductive quenching of the photocatalyst by tributylamine. Avoiding strongly reducing photocatalysts as well as strong base, these mild reaction conditions allowed for the expansion of the substrate scope to accommodate also aldehyde and ester substituents. 100 % conversion was obtained after 48 h of irradiation. In this way a wide variety of cyclized products and their corresponding hydrodehalogenated products were obtained as isolated and pure compounds, in the vast majority of cases.

Indexed as

BHASGreen lightIronNHC ligandPhotoredox catalysis

Identifiers

PMID39981893
PMCPMC11979687

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.