Evidence map›Paper›PMID 39981825›Full record

ArticleAmerican journal of physiology. Cell physiology2025

A mechanism of CALHM1 ion channel gating.

Zhongming Ma, Usha Paudel, Maria Wang, J Kevin Foskett

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhongming MaDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0002-6404-6214
Usha PaudelDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Maria WangDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
J Kevin FoskettDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0002-8854-0268

Funding

Molecular physiology of CALHM ion channelsR01DC018278 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2020 to 2024
$2.7M
Role of CALHM1 ion channel in taste transductionR01DC012538 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2013 to 2017
$1.7M
HHS | National Institutes of Health (NIH) DC018278NIDCD NIH HHS R01 DC012538NIDCD NIH HHS R01 DC018278
6 · The paper itself

Abstract

The calcium homeostasis modulator (CALHM) proteins comprise a family of six genes, some of which have been demonstrated to function as ion channels. CALHM1, the founding member, is an extracellular Ca

Indexed as

Calcium ChannelsIon Channel GatingMembrane GlycoproteinsAnimalsCalciumHumansOocytesXenopus laevisCalciumCalcium ChannelsCALHM1 protein, humanMembrane GlycoproteinsCALHM1gating regulationlarge-pore ion channelruthenium redtaste

Identifiers

PMID39981825
PMCPMC12164053

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.