Evidence map›Paper›PMID 39981557›Full record

ArticleAmerican journal of lifestyle medicine2025

A Randomized, Crossover Trial of a Nutritional Intervention for Rheumatoid Arthritis.

Neal D Barnard, Susan Levin, Lee Crosby, Rosendo Flores, Richard Holubkov, Hana Kahleova

4 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of lifestyle medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01544101 nacompletednot on this map

A Nutritional Intervention for Arthritis

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2011 to 2012Enrolled32ConditionsRheumatoid ArthritisArmsVegan Diet, dietary supplement omega3 fatty acids aand vitamins
NCT01700881 nacompletednot on this map

A Nutrition Intervention for Arthritis-2

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2012 to 2020Enrolled6ConditionsRheumatoid ArthritisArmsPlant-based diet, Supplement
NCT03417648 nacompletednot on this map

A Nutrition Intervention for Arthritis-3

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2018 to 2018Enrolled8ConditionsRheumatoid ArthritisArmsPlant-based diet, Supplement
NCT03580681 nacompletednot on this map

A Nutrition Intervention for Arthritis-4

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2018 to 2020Enrolled2ConditionsRheumatoid ArthritisArmsPlant-based diet, Supplement
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Neal D BarnardGeorge Washington University School of Medicine & Health Science; Physicians Committee for Responsible Medicine, Washington, DC, USA.ORCID https://orcid.org/0000-0003-1635-3532
Susan LevinPhysicians Committee for Responsible Medicine, Washington, DC, USA.
Lee CrosbyPhysicians Committee for Responsible Medicine, Washington, DC, USA.
Rosendo FloresPhysicians Committee for Responsible Medicine, Washington, DC, USA.ORCID https://orcid.org/0000-0002-5485-9000
Richard HolubkovSchool of Medicine, University of Utah, Salt Lake City, UT, USA.
Hana KahleovaPhysicians Committee for Responsible Medicine, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the effects of a dietary intervention on arthritis pain and disease severity, 44 adults previously diagnosed with rheumatoid arthritis were randomly assigned to a Diet phase (vegan diet for 4 weeks, elimination of additional foods for 3 weeks, and then reintroduction of the eliminated foods individually over 9 weeks) or a Supplement (placebo) phase for 16 weeks. After a 4-week washout, they then switched to the opposite phase. The Disease Activity Score-28 (DAS28) decreased from 4.5 to 2.5 (P < .001) in the Diet phase and from 3.2 to 2.9 (P = .41) in the Supplement phase (between-group P = .01). The mean number of swollen joints decreased from 7.0 to 3.3 in the Diet phase (P = .03) and increased from 4.7 to 5 in the Supplement phase (P = .63; between-group P = .047). In a subanalysis excluding individuals who increased medications during the study, DAS28 decreased 1.9 points in the Diet phase (P = .003) and .4 points in the Supplement phase (P = .27; between-group P = .04). In a further subanalysis limited to participants making no medication changes, DAS28 decreased 1.5 points in the Diet phase (P = .009) and .3 points in the Supplement phase (P = .40, between-group P = .11). We conclude that the dietary intervention was associated with symptomatic improvements.

trial registrationClinicaltrials.gov NCT01544101, NCT01700881, NCT03417648, and NCT03580681.

Indexed as

Arthritisdietjoint painnutritionplant-basedvegan

Identifiers

PMID39981557
PMCPMC11836578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.