Evidence map›Paper›PMID 39981512›Full record

ArticleiScience2025

Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice.

Kyvan Dang, Alka Singh, Xin Chen, Jennifer L Cotton, Susu Guo, Xiaodi Hu, Zhipeng Tao, Haibo Liu, Lihua J Zhu, Y Tony Ip and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kyvan DangDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Alka SinghDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Xin ChenDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Jennifer L CottonDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Susu GuoDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Xiaodi HuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Zhipeng TaoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Haibo LiuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Lihua J ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Y Tony IpProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Xu WuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Junhao MaoDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.

Funding

Genetic analysis of damage-induced intestinal stem cell division in DrosophilaR01DK083450 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IP, Y. TONY · 2010 to 2024
$4.7M
Targeting dynamic palmitoylation of TEAD transcription factorsR01CA238270 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAO, JUNHAO, WU, XU · 2019 to 2023
$2.7M
Chemical approach to study autopalmitoylation of transcription factorsR01DK107651 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LUO, XUELIAN, WU, XU · 2016 to 2020
$1.9M
Dependence for TEAD transcription factors in intestinal development and polyposisR01DK127180 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MAO, JUNHAO · 2020 to 2024
$1.9M
Mechanism of YAP/TAZ crosstalk with Wnt signalingR01DK127207 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MAO, JUNHAO · 2021 to 2024
$1.5M
NCI NIH HHS R01 CA238270NIDDK NIH HHS R01 DK083450NIDDK NIH HHS R01 DK107651NIDDK NIH HHS R01 DK127180NIDDK NIH HHS R01 DK127207
6 · The paper itself

Abstract

Intestinal homeostasis is tightly regulated by the reciprocal interaction between the gut epithelium and adjacent mesenchyme. The Hippo pathway is intimately associated with intestinal epithelial homeostasis and regeneration; however, its role in postnatal gut mesenchyme remains poorly defined. Here, we find that removal of the core Hippo kinases Lats1/2 or activation of YAP in adult intestinal smooth muscle layers has largely no effect; however, Hippo-YAP signaling in the niche-forming Gli1+ mesenchymal cells plays intrinsic roles in regulating intestinal homeostasis. We find that Lats1/2 deletion drives robust mesenchymal over-proliferation, and YAP activation in Gli1+ pericryptal cells disrupts the intestinal epithelial-mesenchymal crosstalk via promoting Wnt ligand production. We show that YAP is upregulated in the stroma during dextran sodium sulfate (DSS)-induced injury, and mesenchymal YAP activation facilitates intestinal epithelial regeneration. Altogether, our data suggest an important role for mesenchymal Hippo-YAP signaling in the stem cell niche during intestinal homeostasis and pathogenesis.

Indexed as

Cell biologyMolecular biology

Identifiers

PMID39981512
PMCPMC11841074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.