ArticleCureus2025
Occurrence of Multiple Psychiatric Comorbidities in a Child with Neurofibromatosis Type 1 (NF1): A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Neurofibromatosis type 1 (NF1) is a complex genetic disorder often associated with neurocutaneous manifestations and cognitive impairments. This case report examines a nine-year-old child with NF1 who presented with multiple psychiatric comorbidities, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and developmental disorder of scholastic skills (DDSS). The child exhibited significant impairments in daily functioning and academic performance. Comprehensive assessments identified deficits in social communication and repetitive behaviors consistent with ASD, as well as symptoms of inattention and hyperactivity indicative of ADHD. Furthermore, the child struggled with reading, writing, and mathematics, consistent with DDSS. This report highlights the importance of diagnostic evaluations in children with NF1 to identify and address co-occurring psychiatric conditions. The association between NF1 and these comorbidities suggests a similar neurobiological basis, potentially involving disrupted neural pathways and altered brain development. Early intervention strategies, including behavioral therapies, educational support, and appropriate pharmacological treatments, were implemented to address the child's needs. This case emphasizes the importance of personalized approaches to improve developmental, cognitive, and psychological outcomes for children with NF1 and multiple psychiatric comorbidities. Further research is necessary to better understand the mechanisms driving these associations and to guide treatment strategies.
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