Evidence map›Paper›PMID 39981351›Full record

ArticleFrontiers in cardiovascular medicine2025

Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide.

Marla Christen, Aline Buergin, Maamed Mademilov, Laura Mayer, Simon R Schneider, Mona Lichtblau, Talant M Sooronbaev, Silvia Ulrich, Konrad E Bloch, Michael Furian

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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Marla ChristenDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.
Aline BuerginDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.
Maamed MademilovSwiss-Kyrgyz High Altitude Medicine and Research Center, Bishkek, Kyrgyzstan.
Laura MayerDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.
Simon R SchneiderDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.
Mona LichtblauDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.
Talant M SooronbaevSwiss-Kyrgyz High Altitude Medicine and Research Center, Bishkek, Kyrgyzstan.
Silvia UlrichDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.
Konrad E BlochDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.
Michael FurianDepartment of Respiratory Medicine, University and University Hospital of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In patients with chronic obstructive pulmonary disease (COPD), oxygen delivery to the heart may be impaired during travel at altitude. We assessed electrocardiogram (ECG)-derived signs of cardiac ischemia and the effects of preventive acetazolamide therapy in COPD patients traveling to high altitudes. Methods: Patients with COPD [Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) grades 2-3] and a predicted forced expiratory volume in 1 s (FEV Results: At 760 m, 3 of 49 (6%) patients randomized to placebo and 3 of 50 (6%) randomized to acetazolamide showed a post-exercise STE. At 3,100 m under placebo, two (4%) new STEs developed and one (2%) disappeared compared to 760 m ( Conclusions: In lowlanders with moderate to severe COPD ascending to 3,100 m, no ECG-derived signs of cardiac ischemia emerged neither at rest nor post-exercise and this was not modified by preventive acetazolamide therapy.

Indexed as

acetazolamideaVRcardiac ischemiaCOPDelectrocardiogramhypoxia

Identifiers

PMID39981351
PMCPMC11839630

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.