SynthesisFrontiers in cardiovascular medicine2025
A systematic review and meta-analysis of the impact of left bundle branch area pacing on right ventricular function.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Incidence and Predictors of Acute Tricuspid Regurgitation Worsening After Left Bundle Branch Area Pacing.Circulation reports · 2026Article
- Left bundle branch pacing optimized right ventricular resynchronization in a patient with severe right ventricular dilatation.HeartRhythm case reports · 2026Article
- Advanced Cardiac Imaging for Risk Prediction of Pacing-Induced Cardiomyopathy: A Narrative Literature Review.Journal of clinical medicine · 2026Review
- Sex Differences and Long-Term Outcomes in Patients with Left Bundle Branch Area Pacing Compared with Right Ventricular Pacing.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to systematically evaluate and perform a meta-analysis on the effects of LBBAP on right ventricular (RV) function by collecting data on Right Ventricular Fractional Area Change (RV-FAC), Tricuspid Annular Plane Systolic Excursion (TAPSE), Interventricular Mechanical Delay (IVMD), and the incidence of tricuspid regurgitation (TR) worsening in Left bundle branch area pacing (LBBAP) patients. Methods: A comprehensive search was conducted for studies published from the establishment of the respective databases until October 2024 in PubMed, Embase, Web of Science, and the Cochrane Library. After screening and data extraction, the Newcastle-Ottawa Scale was used for the quality assessment of the included cohort studies, and meta-analysis was performed using R software. The effect size was estimated using either a random-effect model or a fixed-effect model, with odds ratio (OR) and mean difference (MD). Results: A total of 14 studies were included, analyzing 1,555 LBBAP patients. The meta-analysis revealed that compared with intrinsic conduction, LBBAP implantation significantly improved RV-FAC (MD = 1.93; 95% CI: 0.64-3.23, Conclusion: This meta-analysis demonstrates the superiority of LBBAP over intrinsic conduction in improving RV systolic function. Compared to RVP, LBBAP significantly enhances biventricular synchronization. Furthermore, LBBAP also improves ventricular synchronization in patients with RV dysfunction or RBBB.
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