ArticleFrontiers in immunology2025
Pre-transplant T-cell clonal analysis identifies CD8
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Pre-transplant TCR Network Topology Predicts Kidney Allograft Rejection Independent of HLA Mismatch.bioRxiv : the preprint server for biology · 2026Article
- Coordinated circulating and tissue-based T cell responses precede xenograft rejection.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Introduction: Responses to allogeneic human leukocyte antigen (HLA) molecules limit the survival of transplanted organs. The changes in T-cell alloreactivity that contribute to this process, however, are not fully understood. We defined a set of donor reactive T-cell clones (DRTC) with the goal to elucidate signatures of kidney allograft rejection. Methods: DRTC were identified pretransplant using an anti-donor mixed lymphocyte reaction assay: CFSE-diluting CD4 Results: In patients with an abnormal biopsy, the majority of CD8 Discussion: The findings of our study add to our understanding of T-cell alloreactivity following kidney transplantation and provide evidence for the role of pre-defined alloreactive T-cells in the development of allograft rejection.
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