ArticleFrontiers in immunology2025
Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- [Toxicity of lunar dust simulant exposure via the digestive system: Microbiota dysbiosis and multi-organ injury].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- [Effects of lunar soil simulant and Earth soil on lung injury in mice].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Hazards of lunar surface exploration: determining the immunogenicity/allergenicity of lunar dust.Frontiers in immunology · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Due to cosmic radiation bombardment and over 4 billion meteorite and micrometeoroid impacts on the airless Moon, the lunar surface is covered by a layer of fine, reactive dust. Very little is known regarding the toxicity of lunar dust on human physiology. This study assessed airborne lunar dust exposure in rats on localized pulmonary and systemic immune parameters. Methods: Rats were exposed to 0 (air only), 20.8 (low), and 60.6 (high) mg/m Results: Untreated lavage fluid was comprised primarily of pulmonary macrophages. High-dose lunar dust inhalation (60.6 mg/m Conclusion: Exposures to high concentrations of lunar dust resulted in persistent lung inflammation and some systemic immune dysregulation that did not subside even 13 weeks after the dust exposure. This information is beneficial in deriving an exposure limit to airborne lunar dust and for spacecraft engineers considering dust mitigation systems in lunar landers or habitats.
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