Evidence map›Paper›PMID 39981152›Full record

ArticleMedical archives (Sarajevo, Bosnia and Herzegovina)2024

CD56 Expression in Spleen Tissue Pathology and Its Implications in the Development of Type 1 Diabetes: Insights from Diabetic Rat Models.

Suha Khayri Ababneh, Osama Odat, Ali Ata Alsarhan, Jumanah D Al-Shawabkeh, Futoon Abedrabbu Al-Rawashde, Rawan Al-Jaloudi, Moath Alqaraleh, Nihad Al-Othman, Ahed J Alkhatib

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Article in Medical archives (Sarajevo, Bosnia and Herzegovina), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Suha Khayri AbabnehDepartment of Allied Medical Sciences Zarqa University College Al-Balqa Applied University Zarqa Jordan.
Osama OdatDepartment of Allied Medical Sciences Zarqa University College Al-Balqa Applied University Zarqa Jordan.
Ali Ata AlsarhanDepartment of Allied Medical Sciences Zarqa University College Al-Balqa Applied University Zarqa Jordan.
Jumanah D Al-ShawabkehDepartment of Allied Medical Sciences Zarqa University College Al-Balqa Applied University Zarqa Jordan.
Futoon Abedrabbu Al-RawashdeDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan.
Rawan Al-JaloudiDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan.
Moath AlqaralehDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan.
Nihad Al-OthmanDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Palestine.
Ahed J AlkhatibDepartment of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of beta cells in the pancreas. Objective: This study's goals were to look at how much CD56 was expressed in the spleen tissue of rats with type 1 diabetes and compare it to rats that were not diabetic. Methods: The method used in this study was to give rats type 1 diabetes by giving them Alloxan (120 mg/kg). The rats had diabetes for one month. As soon as the experiment was over, all the animals were put down and prepared for normal biochemical, histology, and immunohistochemical tests. Results: The study results revealed that the biochemical findings including glucose, cholesterol, and triglycerides in diabetic group were more significantly higher than that in the control group. The spleen tissue of diabetic rats was more inflamed than that of the control group, as shown by histological results. CD56 expression was much lower in the rats of diabetic group compared to the rats in the control group. Conclusion: When looked at as a whole, CD56's role in diabetes seems to have been lost. This explains why people with type 1 diabetes have inflammatory problems.

Indexed as

CD56 AntigenDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1SpleenAnimalsBlood GlucoseDisease Models, AnimalMaleRatsRats, WistarBlood GlucoseCD56 AntigenCD56expressionhistologyimmunohistochemistryType 1 diabetes

Identifiers

PMID39981152
PMCPMC11838832

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