ArticleFrontiers in medicine2025
Clinical study, network pharmacology, and molecular docking of Kunxian capsule in treating idiopathic membranous nephropathy.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Baicalin ameliorates podocyte injury and renal function impairment in idiopathic membranous nephropathy by inhibiting the AGE/RAGE signaling.Renal failure · 2026Article
- The Mechanism and Application of Traditional Chinese Medicine Nano-Formulations in the Treatment of Renal Fibrosis.International journal of nanomedicine · 2026Review
- The effects of traditional Chinese botanical medicine on membranous nephropathy.Frontiers in pharmacology · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Objective: A new Methods: We conducted a retrospective study of 39 patients with IMN who received KX to investigate its efficacy and side effects of KX in treating IMN. We also used network pharmacology and molecular docking methods to explore the potential mechanism of action of KX in IMN. Results: In patients with IMN receiving KX treatment, 24 h urine protein was markedly decreased, whereas serum albumin levels increased. The overall clinical response rate was 79.49% after 6 months of treatment, and there were no significant adverse events. Quercetin, luteolin and kaempferol were the main bioactive ingredients of KX in treating IMN. AKT1, IL6, and TNF were core targets. The main potential mechanism of KX in treating IMN were pathways involved in cancer, the AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis. Molecular docking results showed that the binding force between the active ingredient and core target was relatively stable. Conclusion: KX is a safe and effective treatment option for IMN and can effectively improve serum albumin and 24 h urine protein levels in patients with IMN. This study preliminarily reveals the possible mechanism of KX in the treatment of IMN and provides a theoretical basis for future clinical research.
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