Evidence map›Paper›PMID 39981069›Full record

ArticleOpen forum infectious diseases2025

Residual Symptoms and Quality of Life After Treated Lyme Neuroborreliosis: Case-Control Study (QoLYME).

Julie Foret, Anne-Julie Paren, Souheil Zayet, Catherine Chirouze, Vincent Gendrin, Kevin Bouiller, Timothée Klopfenstein

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diagnostics (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julie ForetDepartment of Infectious and Tropical Diseases, CHU Besançon, Besançon, France.
Anne-Julie ParenDepartment of Infectious and Tropical Diseases, Nord Franche-Comté Hospital, Trevenans, France.
Souheil ZayetDepartment of Infectious and Tropical Diseases, Nord Franche-Comté Hospital, Trevenans, France.
Catherine ChirouzeDepartment of Infectious and Tropical Diseases, CHU Besançon, Besançon, France.
Vincent GendrinDepartment of Infectious and Tropical Diseases, Nord Franche-Comté Hospital, Trevenans, France.
Kevin BouillerDepartment of Infectious and Tropical Diseases, CHU Besançon, Besançon, France.ORCID https://orcid.org/0000-0002-2177-4318
Timothée KlopfensteinDepartment of Infectious and Tropical Diseases, Nord Franche-Comté Hospital, Trevenans, France.ORCID https://orcid.org/0000-0003-4334-9889

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Earlier studies revealed that 10%-50% of patients reported remaining complaints after treatment for Lyme neuroborreliosis (LNB). The aim of our study was to assess symptoms and quality of life in patients with diagnosed and treated LNB and to compare them with findings in the general population. Methods: Adults with LNB receiving adequate antibiotics were included between 2015 and 2021 in 2 tertiary hospitals. Two controls without Lyme borreliosis history were included for each case patient, matched by age and geographic area. All participants were interviewed to answer a standardized questionnaire. Fatigue was assessed by the Fatigue Severity Scale (FSS) and quality of life by the 12-Item Short Form Survey, including physical component summary (PCS) and mental component summary (MCS) scores. Results: Fifty-three patients and 104 controls were included. The mean age (SD) was 62 (13) years in both groups; 66% were male in the LNB group and 44% in the control group ( Conclusions: Several symptoms were similar in patients with LNB and controls. Quality of life was slightly impaired in patients with LNB and PCS scores were lower, but there were no differences in MCS or FSS scores. Reassurance and specific rehabilitation measures could be provided to these patients.

Indexed as

fatigueLyme borreliosisLyme neuroborreliosisquality of liferesidual symptoms

Identifiers

PMID39981069
PMCPMC11842133

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.