ArticleClinical case reports2025
A Case of Trimethoprim-Sulfamethoxazole Associated Aseptic Meningitis.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most cases of aseptic meningitis, or nonsuppurative meningitis, are caused by viruses or systemic diseases. Nonetheless, drug-induced aseptic meningitis should be considered in the differential diagnosis, particularly with the recent use of antibiotics and nonsteroidal anti-inflammatory drugs. We describe a case of meningitis associated with the use of Trimethoprim-Sulfamethoxazole (TMP-SMX) in a 72-year-old male with comorbidities. A 72-year-old male with a history of diabetes, hypertension, Parkinson's disease, benign prostatic hyperplasia, and a recent use of TMP-SMX for a urinary tract infection (UTI) presented with altered mental status, neck rigidity, tachycardia, and a fever of 102.8°F. CT scan of the head and abdomen and chest x-ray revealed no significant findings. Empiric treatment with ampicillin, vancomycin, acyclovir, and ceftriaxone was initiated after two failed attempts at lumbar puncture, resulting in the improvement of all symptoms except for altered mental status within 24 h. Analysis of CSF, obtained via a successful subsequent lumbar puncture, was negative for microorganisms. The patient was labeled as a case of TMP-SMX-induced aseptic meningitis (TSIAM) due to the recent use of the drug for UTI. All the antibiotics and antivirals were discontinued, and all his symptoms resolved within 5 days of presentation. TSIAM is a diagnosis of exclusion, and a low threshold of suspicion should be maintained when CSF microscopy and culture show no microorganisms. This case illustrates the significance of prompt recognition of TSIAM and highlights the importance of thorough history-taking in preventing complications associated with drug-induced aseptic meningitis, thereby improving patient outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.