Evidence map›Paper›PMID 39980858›Full record

ArticlePCN reports : psychiatry and clinical neurosciences2025

Family study of bipolar disorder with comorbid anxiety disorder points to

Hiroaki Maki, Naomi Sakai, Muneko Kataoka, Kumiko Fujii, Yuki Kageyama, Takashi Hayama, Koji Matsuo, Masaki Nishioka, Tadafumi Kato

Abstract read
In one paragraph

Article in PCN reports : psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The anxious bipolar phenotype: clinical complexity and treatment response.International journal of bipolar disorders · 2026
    Article
  2. Article
  3. Family study of bipolar disorder with comorbid anxiety disorder points toPCN reports : psychiatry and clinical neurosciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiroaki MakiDepartment of Psychiatry and Behavioral Science Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0009-0007-5286-7748
Naomi SakaiDepartment of Psychiatry and Behavioral Science Juntendo University Graduate School of Medicine Tokyo Japan.
Muneko KataokaDepartment of Psychiatry Tokyo Metropolitan Toshima Hospital Tokyo Japan.
Kumiko FujiiDepartment of Psychiatry Shiga University of Medical Science Otsu Japan.ORCID 0000-0001-5616-1899
Yuki KageyamaDepartment of Neuropsychiatry Graduate School of Medicine, Osaka Metropolitan University Osaka Japan.ORCID 0000-0002-9496-9204
Takashi HayamaYokohama Mental Clinic Totsuka Yokohama Japan.
Koji MatsuoDepartment of Psychiatry Saitama Medical University Moroyama Japan.ORCID 0000-0002-2002-5526
Masaki NishiokaDepartment of Psychiatry and Behavioral Science Juntendo University Graduate School of Medicine Tokyo Japan.
Tadafumi KatoDepartment of Psychiatry and Behavioral Science Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0000-0001-7856-3952

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The aim of this study was to provide new insights into the genetics of bipolar disorder (BD) by analyzing BD comorbid with anxiety disorders. Methods: Structured interviews were conducted with BD patients and their parents. Cases were classified into those with comorbid anxiety spectrum (AS) and those without. The family history of patients with BD with comorbid AS was assessed. Focusing on parent-of-origin effects and genomic imprinting from the results, imprinted genes and tested single nucleotide polymorphisms (SNPs) in the identified genes were investigated for an association with BD by transmission disequilibrium test (TDT) using published whole-exome sequencing data. Results: The incidence of comorbid AS among all the patients with BD analyzed in this study was 39.6%. Patients with BD whose fathers had AS or mood disorders exhibited a significantly higher rate of AS. Among the known imprinted genes, two were associated with BD: Conclusion:

Indexed as

anxiety disordersbipolar disordercomorbiditygenomic imprintingsingle nucleotide polymorphism

Identifiers

PMID39980858
PMCPMC11839488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.