Evidence map›Paper›PMID 39980789›Full record

ArticleEuropean heart journal supplements : journal of the European Society of Cardiology2025

Over 10 years of non-vitamin K antagonist oral anticoagulants: highlights, challenges, and future developments.

Raffaele De Caterina, Simona Chiusolo

Abstract read
In one paragraph

Article in European heart journal supplements : journal of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Raffaele De CaterinaCardio-Thoracic and Vascular Department, Pisa University Hospital and University of Pisa, Via Paradisa, 2, 56125 Pisa, Italy.ORCID https://orcid.org/0000-0003-1637-574X
Simona ChiusoloCardio-Thoracic and Vascular Department, Pisa University Hospital and University of Pisa, Via Paradisa, 2, 56125 Pisa, Italy.ORCID https://orcid.org/0009-0003-1131-2755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decade, non-vitamin K antagonist oral anticoagulants have revolutionized anticoagulation therapy, offering substantial benefits over traditional vitamin K antagonists. Non-vitamin K antagonist oral anticoagulants offer reduced bleeding risks, fixed dosing without frequent monitoring, and fewer drug and dietary interactions. Their effectiveness has been demonstrated in preventing stroke in atrial fibrillation, managing venous thromboembolism, and offering new options for patients with coronary artery disease and cancer-associated thrombosis. However, challenges remain, including bleeding risks, high costs, and limited efficacy in certain patient populations. Current research is focused on addressing these limitations, with Factor XI inhibitors emerging as a promising advancement for safer anticoagulation. This review provides an overview of the clinical highlights, challenges, and future directions of anticoagulation therapy.

Indexed as

Atrial fibrillationFactor XI inhibitorsNon-vitamin K antagonist oral anticoagulantsVenous thromboembolism

Identifiers

PMID39980789
PMCPMC11836674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.