Evidence map›Paper›PMID 39980714›Full record

ArticleCureus2025

Unexpected Spontaneous Regression of Extensively Diffused Hepatocellular Carcinoma.

Taiyo Hirata, Shinya Endo, Naofumi Shirane, Shinya Kawaguchi, Kazuya Ohno

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taiyo HirataGastroenterology, Shizuoka General Hospital, Shizuoka, JPN.
Shinya EndoGastroenterology, Shizuoka General Hospital, Shizuoka, JPN.
Naofumi ShiraneGastroenterology, Shizuoka General Hospital, Shizuoka, JPN.
Shinya KawaguchiGastroenterology, Shizuoka General Hospital, Shizuoka, JPN.
Kazuya OhnoGastroenterology, Shizuoka General Hospital, Shizuoka, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous regression (SR) of malignant tumors is defined as the partial or complete reduction of a tumor without medical intervention. This unusual phenomenon has been reported in various types of malignancies. We present a rare case of a 73-year-old woman with untreated chronic hepatitis C who was diagnosed with extensively diffused hepatocellular carcinoma (HCC) accompanied by a tumor thrombus in the left branch of the portal vein. Remarkably, extensive tumor regression occurred under palliative care. This case highlights the potential mechanisms responsible for SR of HCC, including tumor hypoxia, immune activation, and systemic inflammatory responses, and emphasizes the need for further research to clarify these mechanisms.

Indexed as

chronic hepatitis chepatocellular carcinomaspontaneous regressionsystemic inflammatory responsetumor hypoxia

Identifiers

PMID39980714
PMCPMC11841750

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.