Evidence map›Paper›PMID 39980707›Full record

ArticlePulmonary circulation2025

RNA-Seq and ChIP-Seq Identification of Unique and Overlapping Target Genes and Pathways Regulated by TBX4 in Human Pulmonary Fibroblasts and Pericytes.

Ying Cai, Ling Yan, Joy D Cogan, Lora K Hedges, Bethany Nunley, Nick Negretti, Jennifer M S Sucre, James West, Eric D Austin, Rizwan Hamid

Abstract read
In one paragraph

Article in Pulmonary circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying CaiDivision of Medical Genetics and Genomic Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Ling YanDivision of Medical Genetics and Genomic Medicine Vanderbilt University Medical Center Nashville Tennessee USA.ORCID 0000-0001-5727-3278
Joy D CoganDivision of Medical Genetics and Genomic Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Lora K HedgesDivision of Allergy, Immunology, and Pulmonary Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Bethany NunleyDivision of Medical Genetics and Genomic Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Nick NegrettiMildred Stahlman Division of Neonatology Vanderbilt University Medical Center Nashville Tennessee USA.
Jennifer M S SucreMildred Stahlman Division of Neonatology Vanderbilt University Medical Center Nashville Tennessee USA.
James WestDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA.ORCID 0000-0002-6004-0202
Eric D AustinDivision of Allergy, Immunology, and Pulmonary Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
Rizwan HamidDivision of Medical Genetics and Genomic Medicine Vanderbilt University Medical Center Nashville Tennessee USA.

Funding

Sex Hormones in Pulmonary Arterial HypertensionP01HL108800 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWMAN, JOHN HUGHES · 2012 to 2021
$22.0M
Interventions Against the Molecular Etiology of BMPR2-induced PAHR01HL095797 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEST, JAMES D · 2010 to 2022
$6.7M
Interdisciplinary Training Program in Lung ResearchT32HL094296 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ray Stokes Peebles · 2008 to 2026
$6.3M
Estrogen signaling and energy metabolism in pulmonary arterial hypertensionR01HL134802 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUSTIN, ERIC DOUGLAS · 2018 to 2022
$3.7M
Integrated Molecular and Cellular Drivers of AlveologenesisR01HL168556 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer MalcolmSrygley Sucre · 2023 to 2026
$2.8M
Role of BMPR2 expression in HPAH; implications for novel therapeutic approachesR01HL102020 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAMID, RIZWAN · 2011 to 2015
$2.3M
NHLBI NIH HHS P01 HL108800NHLBI NIH HHS R01 HL095797NHLBI NIH HHS R01 HL102020NHLBI NIH HHS R01 HL134802NHLBI NIH HHS R01 HL168556NHLBI NIH HHS T32 HL094296
6 · The paper itself

Abstract

Transcription factor

Indexed as

ChIP‐seqextracellular matrix (ECM)pulmonary arterial hypertension (PAH)RNA‐seqT‐Box 4 (TBX4)

Identifiers

PMID39980707
PMCPMC11839389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.