Evidence map›Paper›PMID 39980629›Full record

ArticleMaterials today. Bio2025

3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration.

Hanrui Xi, Xihao Jiang, Shilang Xiong, Yinuo Zhang, Jingyu Zhou, Min Liu, Zhigang Zhou, Chengyu Zhang, Shiwei Liu, Zhisheng Long and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hanrui XiDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China.
Xihao JiangSchool of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, No. 1180 Shuanggang East Avenue, Nanchang, Jiangxi, 330013, China.
Shilang XiongDepartment of Orthopedics, Tenth People's Hospital of Tongji University, Shanghai, 200072, China.
Yinuo ZhangDepartment of Orthopedics, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jingyu ZhouDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China.
Min LiuDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China.
Zhigang ZhouDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China.
Chengyu ZhangDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China.
Shiwei LiuDepartment of Joint Surgery, Ganzhou People's Hospital, No. 16, Mei Guan Road, Zhang Gong District, Ganzhou, Jiangxi, 341000, China.
Zhisheng LongInstitute of Clinical Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, China.
Jianguo ZhouDepartment of Joint Surgery, Ganzhou People's Hospital, No. 16, Mei Guan Road, Zhang Gong District, Ganzhou, Jiangxi, 341000, China.
Guowen QianSchool of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, No. 1180 Shuanggang East Avenue, Nanchang, Jiangxi, 330013, China.
Long XiongDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exacerbation of osteolysis in osteoporotic bone defects presents a significant challenge for implant-based treatments. This underscores the urgent need to develop implants that actively mitigate osteolysis while simultaneously promoting bone regeneration. In this study, the osteogenic potential of mesoporous bioactive glass (MBG) and β-tricalcium phosphate (β-TCP) was combined with the anti-bone resorption property of Ga doping. Ga-MBG was synthesized using a self-transformation method and subsequently incorporated into β-TCP at concentrations of 5 wt%, 10 wt% and 15 wt%. Scaffolds were prepared using extrusion-based 3D printing. The cytocompatibility of the composite scaffolds and their regulatory effects on the differentiation of osteoblasts and osteoclasts were systematically examined. In addition, the molecular mechanisms underlying bone regeneration and osteolysis regulation in osteoblasts were explored. Subsequently, cranial defects were repaired in a rat model of osteoporosis to assess the therapeutic efficacy and biological safety of the optimal concentration of the Ga-MBG/TCP composite scaffold. These findings indicated that the 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis. These results provide a foundation for further investigation into the optimal concentration of Ga-MBG implants and highlight their potential application in future therapies for osteoporotic bone defects.

Indexed as

Bone regenerationGallium dopingMesoporous bioglassOsteoporosisTricalcium phosphate

Identifiers

PMID39980629
PMCPMC11840525

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.