ArticleFrontiers in oncology2025
A comprehensive analysis and comparative study of the trends in thyroid cancer burden in China and globally from 1990 to 2021, with projections for the next 15 Years.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Signaling pathways and targeted therapy in high‑risk refractory thyroid cancer: From bench to bedside (Review).International journal of oncology · 2026Review
- DSDFF-YOLO: an automated computer-aided diagnostic method for post-therapy radioiodine whole-body scan.European radiology · 2026Article
- Global and China burden of maternal sepsis and infections: a systematic global burden of disease 2021 analysis with projections to 2036.The Journal of the Egyptian Public Health Association · 2026Article
- Factors affecting thyroid nodule among coal miners: a prospective nested case-control study in Xinjiang, China.Frontiers in public health · 2026Article
- Knowledge, Attitudes, and Practices Regarding Iodine-131 Therapy and Their Association with Depression and Anxiety Among Postoperative Thyroid Cancer Patients Undergoing I-131 Treatment.Patient preference and adherence · 2026Article
- Spatial and temporal distribution of thyroid cancer incidence in China: An ecological study based on a national registry.PloS one · 2026Article
- Association between triglyceride-glucose index and papillary thyroid carcinoma among Chinese adults with thyroid nodules.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to analyze the trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of thyroid cancer across gender and age groups in China and globally from 1990 to 2021, using data from the Global Burden of Disease (GBD) database. Additionally, it projects the trends in thyroid cancer burden for the next 15 years for both China and the global population. Materials and methods: Thyroid cancer-related data were extracted from the 2021 GBD dataset. The average annual percentage change (AAPC) and the corresponding 95% confidence intervals (95% CI) were calculated using Joinpoint regression to reflect trends in the thyroid cancer burden. R software was used to perform a gender- and age-specific analysis and visualize the trends in thyroid cancer burden for both China and the global population. Furthermore, the Autoregressive Integrated Moving Average (ARIMA) model was employed to project the trends in thyroid cancer burden over the next 15 years. Results: The results indicate a rising trend in the incidence and prevalence of thyroid cancer both in China and globally. Conversely, the mortality rate and DALYs show a declining trend over the same period. Age-specific analysis revealed that thyroid cancer is most prevalent among individuals aged 50-64. Gender-specific analysis indicated that the incidence rate is higher in females than in males. Projections for the next 15 years show that the age-standardized incidence rates for both males and females are expected to continue rising in China and globally. While the age-standardized mortality rate for females is projected to decline significantly, the mortality rate for males is predicted to stabilize. Conclusion: Between 1990 and 2021, the number of thyroid cancer cases has increased both in China and globally, while the mortality rate has shown a marked decline. This trend is expected to persist over the next 15 years. The growing population affected by thyroid cancer reflects a substantial disease burden, making thyroid cancer a significant global public health concern. The formulation of proactive and effective health policies is urgently needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.