Evidence map›Paper›PMID 39980503›Full record

ArticleCase reports in oncology

Splenic Irradiation Preceding Allogeneic Hematopoietic Stem Cell Transplantation as a Possible Risk Factor of Sinusoidal Obstruction Syndrome: A Report of Three Cases.

Shuichi Shirane, Hajime Yasuda, Ayana Uchimura, Yosuke Mori, Tadaaki Inano, Miyuki Tsutsui, Yasuharu Hamano, Miki Ando

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Shuichi ShiraneDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Hajime YasudaDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Ayana UchimuraDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Yosuke MoriDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Tadaaki InanoDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Miyuki TsutsuiDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Yasuharu HamanoDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Miki AndoDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Splenomegaly is frequently encountered in patients with myeloproliferative neoplasms. Splenomegaly is associated with an increased incidence of engraftment failure during allogeneic hematopoietic stem cell transplantation (allo-HSCT), and some centers perform prior low-dose splenic irradiation (LDSI) which has been reported to be both safe and effective. However, we report conflicting results by presenting three allo-HSCT patients undergoing LDSI that subsequently developed sinusoidal obstruction syndrome (SOS). Case Presentation: The underlying diseases of the presented cases were atypical chronic myeloid leukemia, secondary myelofibrosis following essential thrombocythemia, and acute myeloid leukemia transforming from myeloproliferative neoplasm, unclassifiable. Endothelial Activation and Stress Index (EASIX) scores of the 3 patients were 0.40, 3.82, and 4.40, respectively. Conclusion: SOS is a potentially fatal complication of allo-HSCT, and the mortality rates of severe cases are reported to be above 80%. LDSI has not been recognized as a risk factor of SOS to date. Alternative management methods of splenomegaly during allo-HSCT such as ruxolitinib administration may be safer compared to LDSI.

Indexed as

Endothelial Activation and Stress Index scoreLow-dose splenic irradiationRuxolitinibSinusoidal obstruction syndromeSplenomegalyVeno-occlusive disease

Identifiers

PMID39980503
PMCPMC11627584

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