ArticleOrthopedic reviews2025
Neurophysiology of ACL Injury.
Article in Orthopedic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural activity differences and their functional and clinical correlates after anterior cruciate ligament reconstruction: A systematic review of task-based fMRI studies.Experimental brain research · 2026Pooled it
- ACL reconstruction postoperative rehabilitation in China: a bibliometrics study and visualization analysis via CiteSpace.Frontiers in rehabilitation sciences · 2026Pooled it
- Effects of contralateral knee functional training on knee function, pain, kinesiophobia, plantar load distribution, and stance-phase parameters after anterior cruciate ligament reconstruction: a single-blind, randomised controlled trial.BMC musculoskeletal disorders · 2026Trial
- Reconstruction After an Anterior Cruciate Ligament Injury Does Not Reduce the Osteoarthritis Risk But Lowers the Total Knee Arthroplasty Rate: A Systematic Review and Meta-analysis.Orthopaedic journal of sports medicine · 2026Review
- Persistence of mechanoreceptors in ACL remnants: a histological and immunohistochemical analysis of 128 patients.Journal of orthopaedic surgery and research · 2026Article
- EEG-Based Cortical Alterations in Patients Following Total Hip and Knee Arthroplasty Due to Osteoarthritis: Pre- and Post-Operative Assessment.Brain and behavior · 2026Article
- Utilization of machine learning to identify lower extremity biomechanical predictors of rupture in a validated cadaveric model of ACL injury.Scientific reports · 2026Article
- Quadriceps muscle force magnitude and control in the knee scheduled for arthroplasty versus the contralateral knee: A cross-sectional study in patients with end-stage osteoarthritis.Knee surgery & related research · 2026Article
- Countermovement Jump and Quantitative Electroencephalography Assessment in Division I Football Athletes: An Exploratory Neurophysiological Study of Return‑to‑Play Readiness.International journal of sports physical therapy · 2026Article
- ACL Rehabilitation Plateaus Across Athlete Populations: Two Case Reports and a Clinical Framework for Identifying Functional Stagnation.International journal of sports physical therapy · 2026Article
- Neuromusculoskeletal alterations after ACL reconstruction: a cross-sectional study of cortical activity, motor response, and psychological readiness.BMC sports science, medicine & rehabilitation · 2025Article
- Impact of early vs. delayed physical therapy on functional recovery, proprioception, and return to sport after anterior cruciate ligament (ACL) reconstruction: a cross-sectional study.Journal of orthopaedic surgery and research · 2025Article
- Neurosciences and Sports Rehabilitation in ACLR: A Narrative Review on Winning Alliance Strategies and Connecting the Dots.Journal of functional morphology and kinesiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurophysiology of ACL injury extends beyond the mechanical rupture of the ligament to encompass profound alterations in the central and peripheral nervous systems, impacting sensorimotor integration and neuromuscular control. The ACL, densely populated with mechanoreceptors, plays a critical role in joint proprioception, dynamically regulating knee stability through complex neural circuits that connect to the spinal cord and brain. When disrupted by injury, these neural pathways contribute to delayed muscular activation, altered motor planning, and compromised joint stability. Such neuromechanical deficits increase the likelihood of reinjury and highlight the need for comprehensive neuroplastic rehabilitation. Neuroplastic therapy, employing tools like external focus strategies, stroboscopic glasses, smartboards, and virtual reality, aims to restore and enhance neural connectivity, sensory integration, and motor coordination. These advanced tools target distinct phases of motor learning, promoting automaticity and resilience in movement patterns. By integrating visual-cognitive, proprioceptive, and reflexive controls, this therapeutic approach not only accelerates recovery but also optimizes performance and reduces the risk of re-injury, representing a paradigm shift in ACL rehabilitation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.