Evidence map›Paper›PMID 39980462›Full record

ArticleACS applied materials & interfaces2025

Development of Engineered Microparticles for Investigating Enzymatic Degradation of Proteins and Peptides within Phagosomes.

Masahiro Fukuda, Grace Lin, Yang Liu, Grace Hammel, Abigail Kizer, Maryam Ayazi, Sailesti Joshi, Yuan Liu, Yi Ren, Jingjiao Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Masahiro FukudaDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida 32310-2870, United States.
Grace LinDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida 32310-2870, United States.
Yang LiuCollege of Medicine, Florida State University, Tallahassee, Florida 32306-4370, United States.
Grace HammelCollege of Medicine, Florida State University, Tallahassee, Florida 32306-4370, United States.
Abigail KizerCollege of Medicine, Florida State University, Tallahassee, Florida 32306-4370, United States.
Maryam AyaziCollege of Medicine, Florida State University, Tallahassee, Florida 32306-4370, United States.
Sailesti JoshiDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida 32310-2870, United States.
Yuan LiuDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida 32310-2870, United States.
Yi RenCollege of Medicine, Florida State University, Tallahassee, Florida 32306-4370, United States.
Jingjiao GuanDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida 32310-2870, United States.ORCID 0000-0002-8389-4067

Funding

Exploring the therapeutic mechanisms of proinflammatory myelin-laden macrophages retention in the injured spinal lesion coreR01NS126468 · NINDS · FLORIDA STATE UNIVERSITY · PI Richard S Nowakowski · 2022 to 2026
$1.8M
Development of a technique for specific labelling phagosome-derived membranous structures in dendritic cellsR03AI171974 · NIAID · FLORIDA STATE UNIVERSITY · PI GUAN, JINGJIAO · 2022 to 2023
$142k
NIAID NIH HHS R03 AI171974NINDS NIH HHS R01 NS126468
6 · The paper itself

Abstract

Phagocytosis involves the engulfment and enzymatic degradation of particulate objects by phagocytes in a compartment called a phagosome. The degradation mechanisms for natural phagocytic objects such as proteins and peptides are not well understood. To explore this, we developed a novel method using microparticles made of proteins and/or peptides and poly(

Indexed as

PeptidesPhagosomesAcrylic ResinsAnimalsHistonesMacrophagesMiceOvalbuminPhagocytosisPolylysineRAW 264.7 CellsAcrylic ResinsHistonesOvalbuminPeptidesPolylysinepoly-N-isopropylacrylamidedegradationlayer-by-layer assemblymicrocontact printingphagocytosisprotein

Identifiers

PMID39980462
PMCPMC12579385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.