ArticleJournal of Alzheimer's disease : JAD2025
Daily fluid intake and brain amyloid deposition: A cohort study.
Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Hydrate to keep the amyloid away.Journal of Alzheimer's disease : JAD · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
BackgroundLittle information is yet available for the association between daily water intake, a modifiable lifestyle factor, and Alzheimer's disease (AD) pathology and cerebrovascular injury in the living human brain.ObjectiveOur aim was to explore the correlation between daily fluid intake and in vivo AD pathologies (i.e., amyloid-β (Aβ) and tau) and cerebrovascular injury.Methods287 cognitively normal (CN) older adults completed extensive clinical assessments, daily fluid intake evaluations, and multimodal brain imaging at both the initial baseline and the subsequent 2-year follow-up.ResultsLow daily fluid intake was significantly associated with a higher level or a more rapid increase of Aβ deposition, especially in apolipoprotein E4 negative individuals. Meanwhile, low daily fluid intake was cross-sectionally related with cerebrovascular injury.ConclusionsOur findings suggest that high daily fluid intake is associated with decreased brain amyloid deposition, indicating that sufficient daily fluid intake may be helpful for prevention of AD.
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