ArticleEquine veterinary journal2025
Characterising equine abdominal lipomata: Can histological features improve the understanding of pathogenesis and risk?
Article in Equine veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Risk factors for strangulating lipoma obstruction and lipomata in horses.Equine veterinary journal · 2026Article
- Risk factors for equine strangulating lipoma colic: An international, case-control study.Equine veterinary journal · 2026Article
- Characterising equine abdominal lipomata: Can histological features improve the understanding of pathogenesis and risk?Equine veterinary journal · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundStrangulating lipomata are the most common cause of small intestinal strangulating obstruction. Evaluation of histological features of pathological and non-pathological lipomata, and the histological properties of omental and retroperitoneal fat have not been described.
objectivesTo characterise histological features of equine abdominal lipomata, omental and retroperitoneal adipose tissue, and associations between them. STUDY
designProspective observational anatomic (gross and histological).
methodsHorses undergoing emergency laparotomy for management of abdominal pain in a single hospital were recruited. Signalment was recorded. Gross features of lipomata that were a cause of strangulating obstruction (pathological lipomata [PAL]), and lipomata that were currently not causing an intestinal obstruction (pedunculated [PEL] or non-pedunculated [NPL]) were recorded. Lipomata that were removed intra-operatively, or following owner-requested euthanasia, as well as omentum or retroperitoneal adipose tissue, where excised routinely as part of routine management (or post-euthanasia) were fixed in 10% neutral-buffered formalin prior to staining (haematoxylin and eosin, picrosirius red). Descriptive statistical analyses were performed. Pearson's chi-square, Fisher's exact or Kruskal-Wallis tests, as appropriate, were used to assess associations. Significance was p < 0.05.
resultsSeventy-four horses were enrolled; 71 lipomata, 48 retroperitoneal adipose samples, and 26 omental samples underwent evaluation. Increasing age was predictive of lipomata presence and PAL/PEL. Neither omental nor retroperitoneal adipose tissue histological features were correlated with lipomata presence or type. PAL were more likely to exhibit capsule formation (PAL: 70%, NPL: 42%, p = 0.03), and had a higher vascular density (median 10.6; IQR: 8.8-16.8; p = 0.05), compared with NPL. PEL were more likely to exhibit steatonecrosis (PEL: 92%, NPL: 33%, p = 0.01) and had increased mineralisation (PEL: 67%, NPL: 17%, p = 0.05) compared with NPL. MAIN LIMITATIONS: Small sample size.
conclusionsHistological features of omental and retroperitoneal fat do not predict presence of lipomata or type. However, there are histological features of PAL and PEL which may be related to pathological potential.
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