Evidence map›Paper›PMID 39980190›Full record

ArticlePhysiological reports2025

L-arginine ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in male metabolic syndrome rats.

Kaito Tagami, Touko Okuzawa, Keisuke Yoshida, Rin Mishima, Natsuki Obara, Asuko Kunimatsu, Mayako Koide, Tamami Teranishi, Koji Itakura, Katsuhide Ikeda and 2 more

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kaito TagamiPathophysiology Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Touko OkuzawaPathophysiology Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Keisuke YoshidaPathophysiology Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Rin MishimaPathophysiology Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Natsuki ObaraDepartment of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan.
Asuko KunimatsuDepartment of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan.
Mayako KoideDepartment of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan.
Tamami TeranishiDepartment of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan.
Koji ItakuraDivision for Medical Research Engineering, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Katsuhide IkedaPathophysiology Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Toyoaki MuroharaDepartment of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kohzo NagataPathophysiology Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0003-0089-6794

Funding

Keiko Nagata N/AKohzo Nagata N/AShigeki Nagata N/ATetsuro Nagata N/AThe ministry of Education, Culture, Sports, Science, and Technology of Japan 21K08078
6 · The paper itself

Abstract

L-Arginine supplementation has beneficial effects on metabolic disorders in rodents. We here investigated the effects of exogenous L-arginine on cardiac pathology and mitochondrial reactive oxygen species (ROS) production and dynamics in DahlS.Z-Lepr

Indexed as

ArginineHeart InjuriesHypertensionMetabolic SyndromeMitochondria, HeartAnimalsDynaminsMaleNADPH Oxidase 4RatsReactive Oxygen SpeciesArginineDnm1l protein, ratDynaminsNADPH Oxidase 4Nox4 protein, ratReactive Oxygen Speciescardiac injuryhypertensionL‐argininemetabolic syndromemitochondria

Identifiers

PMID39980190
PMCPMC11842508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.