ReviewJournal of paediatrics and child health2025
The Current Landscape for Screening and Monitoring of Early-Stage Type 1 Diabetes.
Review in Journal of paediatrics and child health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- A UK Healthcare Professional Perspective on the Implementation of Monitoring in Children and Young People With Early-Stage Type 1 Diabetes: A Qualitative Study.Diabetes, obesity & metabolism · 2026Article
- Continuous glucose monitoring as a tool in early-stage type 1 diabetes.Diabetologia · 2026Review
- Extending the Eisenbarth Model: Stage 0 as a Provisional Framework for Early Risk Stratification and Prevention in Type 1 Diabetes.Journal of diabetes research · 2026Review
- Modulating immune response for the prevention and treatment of type 1 diabetes.Frontiers in immunology · 2026Review
- Optimizing Type 1 Diabetes Screening in People With Family History: A German Perspective.Journal of diabetes science and technology · 2025Review
- Teplizumab for stage 2 type 1 diabetes: a new era in pediatric diabetes prevention.European journal of pediatrics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes (T1D) has two pre-symptomatic phases (stages 1 and 2) with progressive destruction of beta cells which have been identified through longitudinal cohort studies in recent decades. The definition of T1D, with hyperglycaemia that may or may not be symptomatic, is now defined as stage 3. There is growing evidence that screening for stages 1 and 2 reduces rates of diabetic ketoacidosis and prevents long-term complications. These stages can be defined by the presence of islet autoantibodies which are markers of autoimmune beta cell damage. Furthermore, genetic risk scores, which combine a variety of single nucleotide polymorphisms, identify people at high genetic risk of future T1D. Thus, they provide an opportunity to select high-risk individuals for islet autoantibody testing. Individuals identified as having stage 1 or 2 T1D require ongoing monitoring to detect hyperglycaemia and the need for insulin replacement. These individuals may also be eligible for emerging immunotherapies in future to delay progression to stage 3. This review article explores the current evidence for screening and summarises the recommended clinical care for early-stage T1D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.