Evidence map›Paper›PMID 39980067›Full record

ArticleClinical and translational medicine2025

Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice.

Qianqian Dong, Ziwei Liu, Yidan Ma, Xin Chen, Xiaowei Wang, Jinye Tang, Kexin Ma, Chenxi Liang, Mengyu Wang, Xiaoqin Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qianqian DongDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Ziwei LiuDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Yidan MaDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Xin ChenDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Xiaowei WangDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Jinye TangDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Kexin MaDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Chenxi LiangDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Mengyu WangDepartment of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xiaoqin WuDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Yang LiuDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Yaru ZhouDepartment of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Hongyuan YangDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Mingming GaoDepartment of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Cardiovascular Medical Science Center, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID 0000-0002-0589-7633

Funding

Government-funded Clinical Medicine Outstanding Talent Training Project ZF2024081Medical Science Research Project of Health Commission of Hebei Province 20221084Medical Science Research Project of Health Commission of Hebei Province 20231544Natural Science Foundation of Hebei Province H2022206462Natural Science Foundation of Hebei Province H2022206597Natural Science Foundation of Hebei Province H2024206030University of Texas Health Science Center
6 · The paper itself

Abstract

backgroundLiver diseases pose significant health challenges, underscoring the importance of understanding liver regeneration mechanisms. Systemic adipose tissue is thought to be a primary source of lipids and energy during this process; however, empirical data on the effects of adipose tissue deficiency are limited. This study investigates the role of adipose tissue in liver regeneration, focusing on transient regeneration-associated steatosis (TRAS) and hepatocyte proliferation using a Seipin knockout mouse model that mimics severe human lipodystrophy. Additionally, the study explores therapeutic strategies through adipose tissue transplantation.

methodsMale Seipin knockout (Seipin

resultsSeipin

conclusionsSystemic adipose tissue is essential for TRAS and effective liver regeneration following PHx. Its deficiency impairs these processes, while adipose tissue transplantation can restore normal liver function. These findings underscore the critical role of adipose tissue in liver recovery and suggest potential therapeutic strategies for liver diseases associated with lipodystrophies. KEY POINTS: Seipin

Indexed as

Adipose TissueGTP-Binding Protein gamma SubunitsHepatectomyLipid MetabolismLiver RegenerationAnimalsDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLMice, KnockoutBscl2 protein, mouseGTP-Binding Protein gamma Subunitsadipose tissue transplantationhepatocyte proliferationliver regenerationpartial hepatectomySeipin knockout micetransient regeneration‐associated steatosis (TRAS)

Identifiers

PMID39980067
PMCPMC11842221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.