Evidence map›Paper›PMID 39979950›Full record

ArticleMicrobial cell factories2025

The potential application of isoxanthohumol in inhibiting Clostridium perfringens infection by targeting the type IV pili.

Zeyu Song, Yanhong Deng, Jichuan Zhang, Zhongmei Wen, Shui Liu, Xuming Deng, Qiaoling Zhang, Qianghua Lv

Abstract read
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In one paragraph

Article in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeyu Song *Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Yanhong Deng *Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Jichuan ZhangKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Zhongmei WenDepartment of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, 130062, China.
Shui LiuDepartment of Pathogenic Biology, Jilin Medical University, Jilin, China.
Xuming DengKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Qiaoling ZhangKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China. zql@jlu.edu.cn.
Qianghua LvKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China. lvqianghua129@jlu.edu.cn.

Funding

National Natural Science Foundation of China 31772782National Natural Science Foundation of China 32102722
6 · The paper itself

Abstract

backgroundClostridium perfringens (C. perfringens) is an important zoonotic pathogen. The diseases such as necrotic enteritis (NE), enterotoxemia, gas gangrene and food poisoning caused by its infection seriously threaten the lives of both humans and animals. However, under the severe situation of antibiotic resistance, the development of new antibacterial strategies or drugs deserves great attention.

resultsIn this study, we selected the virulence factor Type IV pili (TFP) of C. perfringens as the target for drug screening. The gliding motility, biofilm formation, cell adhesion and antibacterial activity of the natural compound isoxanthohumol (IXN) against C. perfringens were determined. Transmission electron microscopy (TEM), TFP gene transcription analysis and Western blot were used to detect the expression of PilA pilin. The therapeutic effect of IXN on C. perfringens infection was demonstrated through a mouse gas gangrene model. It was confirmed that IXN inhibits the function of TFP by down-regulating TFP-encoding genes and two-component regulatory genes.

conclusionsIn conclusion, our study shows that IXN has the potential to inhibit the function of TFP in C. perfringens and for anti-infection applications.

Indexed as

Anti-Bacterial AgentsClostridium InfectionsClostridium perfringensFimbriae, BacterialXanthonesAnimalsBiofilmsGas GangreneMiceAnti-Bacterial AgentsXanthonesAnti-infectionC. perfringensIsoxanthohumolTFPZoonotic pathogen

Identifiers

PMID39979950
PMCPMC11844124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.