ArticleBMC public health2025
Burden of neurological diseases in Asia, from 1990 to 2021 and its predicted level to 2045: a Global Burden of Disease study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Suicide in neurodegenerative diseases: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Comparative burden and projections of chewing tobacco-attributable lip/oral cavity and esophageal cancers: global and China-specific trends, 2000-2036.Annals of medicine · 2026Article
- The growing burden of dementia in Asia: Comparative insights from Japan, China, and India.The journal of prevention of Alzheimer's disease · 2026Article
- Diverging trends in motor neuron disease burden in China: an ageing-driven increase despite declining age-standardised rates - a GBD 2021 analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Article
- Observational
- Probiotics as a Complementary Medicine in Neurologic Disorders.Health science reports · 2025Article
- The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer's disease.Scientific reports · 2025Article
- Global burden and trends of stroke attributable to kidney dysfunction from 1990 to 2021.Clinical kidney journal · 2025Article
- Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics.Brain sciences · 2025Review
- The global burden of tuberculosis attributable to diet high in processed meat from 1990 to 2021: findings from the Global Burden of Disease Study 2021.Frontiers in nutrition · 2025Article
- Plant-Derived Exosome-Like Nanoparticles: A Promising Therapeutic for Neurological Disorders and Drug Delivery.International journal of nanomedicine · 2025Review
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Abstract
introductionNeurological diseases are a significant contributor to premature mortality and temporary or long-term disability among survivors. Asia serves as an essential region for assessing the shifting burden of these disorders. This study aims to calculate and evaluate the changes in burden of neurological diseases across Asia.
methodsThe Global Burden of Disease database provided data on deaths, disability-adjusted life-years (DALYs), incidence, and prevalence from 1990 to 2021 across Asian subregions and countries. Twelve common neurological diseases were analyzed. Estimated Annual Percent Change were calculated to reveal trends in all the metrics. The Nordpred age-period-cohort model was employed to project the neurological disease burden.
resultsIn 2021, the leading neurological disorders in DALYs were stroke (109,144.87, 95% uncertainty intervals (UI) 95,992.89-123,089.90), headache disorders (25,713.91, 95%UI 4,693.65-54,853.47), and Alzheimer's disease and other dementias (19,156.46, 95% UI 9,137.72-41,421.18). Stroke and degenerative neurological disorder presented the most severe burden in East Asia, while headache disorders were prominent in South Asia. Between 1990 and 2021, Asia's regions showed varying reductions in age-standardized DALYs and age-standardized death rates for neurological diseases, with the steepest decline observed in high-income Asia Pacific (DALYs -2.27, 95% confidence interval (CI) -2.4 to -2.13; ASDR -3.85, 95% CI -4.02 to -3.69). Neurological disease burden was higher in males, peaking at ages 65-74. Projections to 2045 indicate a decline in DALYs for stroke, infectious neurological diseases, Parkinson's disease, and idiopathic epilepsy across most regions of Asia. In contrast, trends for other neurological diseases will vary regionally.
conclusionNeurological diseases were the primary cause of DALYs in 2021, ranking second only to cardiovascular diseases as a leading cause of death. As the aging trend in Asia's population continues to intensify, it is crucial to focus more on the prevention and management of neurological disorders.
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