Evidence map›Paper›PMID 39979881›Full record

ArticleJournal of nanobiotechnology2025

Extracellular vesicle-mediated gene therapy targets BRAF

Di Wang, Liwei Wang, Wei Zhang, Kaicheng Xu, Liang Chen, Ziye Guo, Kaile Wu, Donghua Huang, Yubin Zhao, Minjun Yao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Di Wang *Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Liwei Wang *Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Wei Zhang *Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, PR China.
Kaicheng XuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Liang ChenDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Ziye GuoDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Kaile WuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Donghua HuangDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Yubin ZhaoDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Minjun YaoDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Liming ZhengDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Chenyi YeDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Jisheng RanDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China.
Wei ZhouDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, PR China. weizhou_srrsh@zju.edu.cn.
Xin LiuDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, PR China. xinliuzju@zju.edu.cn.
Jianbin XuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, PR China. xu9709426@zju.edu.cn.

Funding

National Natural Science Foundation of China 32371412National Natural Science Foundation of China 82102598Natural Science Foundation of Zhejiang Province LQ21H060008Natural Science Foundation of Zhejiang Province LY24C100001
6 · The paper itself

Abstract

backgroundPatients with colorectal cancer (CRC) harboring BRAF mutation have a poor prognosis. The median survival time for patients with advanced BRAF

aimThis study aims to develop a precise therapeutic system for BRAF

methodWe first obtained engineered cells capable of stably producing EVs loaded with BRAF

resultEVs-siBRAF

conclusionThe therapeutic EVs we constructed are effective and specific for the BRAF

Indexed as

Colorectal NeoplasmsExtracellular VesiclesGenetic TherapyMAP Kinase Signaling SystemProto-Oncogene Proteins B-rafAnimalsCell Line, TumorFemaleHumansMAP Kinase Kinase 1MiceMice, Inbred BALB CMice, NudeMutationXenograft Model Antitumor AssaysBRAF protein, humanMAP Kinase Kinase 1Proto-Oncogene Proteins B-rafBRAFV600E mutationColorectal cancerExtracellular vesiclesPDX modelsiRNASpecific therapy

Identifiers

PMID39979881
PMCPMC11843959

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.