Evidence map›Paper›PMID 39979813›Full record

Trial reportBMC anesthesiology2025

Cerebral oxygenation and hemodynamic changes during ephedrine and phenylephrine administration for transient intraoperative hypotension in patients undergoing major abdominal surgery: a randomized controlled trial.

Xueyan Li, Yijun Zheng, Jun Zhang

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06925711 (Investigation of the Effect of Hypotensive Anesthesia on Cognitive Functions in Orthognathic Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06925711 completednot on this map

Investigation of the Effect of Hypotensive Anesthesia on Cognitive Functions in Orthognathic Surgery

TypeobservationalSponsorMedipol UniversityRan2022 to 2024Enrolled32ConditionsCognitive Dysfunction, Postoperative ComplicationsArmsNear-Infrared Spectroscopy (NIRS)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xueyan Li *Department of Anaesthesia and Critical Care, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
Yijun Zheng *Department of Anaesthesia and Critical Care, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.ORCID 0000-0002-0163-6401
Jun ZhangDepartment of Anaesthesia and Critical Care, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China. snapzhang@aliyun.com.

Funding

Science and Technology Innovation Plan Of Shanghai Science and Technology Commission No. 22Y11904200
6 · The paper itself

Abstract

backgroundPhenylephrine and ephedrine are frequently used vasopressors for treating intraoperative hypotension. However, their impact on cerebral oxygenation and blood flow remains a subject of debate. This study aims to understand their effects on cerebral oxygen saturation and hemodynamics when used for treatment of intraoperative hypotension.

methodsThe adult patients undergoing major abdominal surgery under general anesthesia were randomly assigned into ephedrine (ED) group or phenylephrine (PE) group. They received an intravenous bolus of either ephedrine or phenylephrine for treating intraoperative transient hypotension. The primary outcome was their effects on regional cerebral oxygen saturation (rScO

resultsForty patients were included in this study. The initial results showed ephedrine increased rScO

conclusionIn the management of intraoperative hypotension, both phenylephrine and ephedrine effectively increase MAP and MCAvm, albeit with their differential effects on CO and HR. It seems that neither vasopressor has a significant impact on cerebral oxygenation and cerebral autoregulation.

Indexed as

AbdomenEphedrineHemodynamicsHypotensionIntraoperative ComplicationsPhenylephrineVasoconstrictor AgentsAdultAgedCerebrovascular CirculationFemaleHumansMaleMiddle AgedOxygenEphedrineOxygenPhenylephrineVasoconstrictor AgentsCardiac outputCerebral autoregulationCerebral blood flow velocityEphedrineHypotensionPhenylephrine

Identifiers

PMID39979813
PMCPMC11841356

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Registered trials

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