Evidence map›Paper›PMID 39979627›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Head and neck cutaneous basal cell carcinoma: a retrospective analysis of tumour features, surgical margins and recurrences.

Pasquale Di Maio, Marco Giudice, Antonio Cavallero, Claudio Carnevale, Guillermo Til-Pérez, Pedro Luis Sarría-Echegaray, Chiara Copelli, Guglielmo Ramieri, Oreste Iocca

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pasquale Di MaioDoctoral Degree in Translational Research in Public Health and High Prevalence Diseases, UIB - Universitat de les Illes Balears, Palma de Mallorca, Spain. pasquale.di-maio@uib.cat.ORCID http://orcid.org/0000-0003-1364-9223
Marco GiudiceDepartment of Otolaryngology-Head and Neck Surgery, Giovanni Borea Civil Hospital, Sanremo, Italy.
Antonio CavalleroDepartment of Otolaryngology-Head and Neck Surgery, Giovanni Borea Civil Hospital, Sanremo, Italy.
Claudio CarnevaleServicio de otorrinolaringologia y cirugía de cabeza y cuello, Clínica Rotger, Palma de Mallorca, Spain.
Guillermo Til-PérezServicio de otorrinolaringologia y cirugía de cabeza y cuello, Clínica Rotger, Palma de Mallorca, Spain.
Pedro Luis Sarría-EchegarayServicio de otorrinolaringologia y cirugía de cabeza y cuello, Clínica Rotger, Palma de Mallorca, Spain.
Chiara CopelliDivision of Maxillofacial Surgery, Department of Interdisciplinary Medicine, University of Bari, Bari, Italy.
Guglielmo RamieriDivision of Maxillofacial Surgery, City of Health and Science of Turin Hospital, University of Turin, Turin, Italy.
Oreste IoccaDivision of Maxillofacial Surgery, City of Health and Science of Turin Hospital, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to analyse the factors affecting the status of surgical margins and recurrence of basal cell carcinoma (BCC) of the head and neck. A secondary aim was to provide detailed demographic, clinical and topographic data to understand the biological behaviour of this skin cancer in head and neck area.

methodsA retrospective analysis was conducted analysing all primary head and neck BCCs treated from July 2014 to October 2021. Chi-square and logistic regression were used to assess the presence of statistically significant associations.

resultsThe study cohort included 307 patients who underwent resection of 377 BCCs. The mean age of the patients was 76.86 years. There were 251 (67%) clean surgical margins, 80 (21%) positive and 46 (12%) closed. Recurrences were observed in 11 (5%) out of 218 BCCs of patients with a minimum follow-up of 24 months. The median follow-up time was 35 months. Positive margin status was significantly associated with BCC of the nose, while clean margin was correlated with neck localization (p<0.05). Clean margin status was linked with direct closure (p<0.05), while positive and closed margins were significantly associated to local flaps (p<0.05). Positive margin status was significantly related to depth of invasion below the dermis (p<0.05).

conclusionThe location, depth of invasion and method of reconstruction of head and neck BCC influence the completeness of surgical resection. Considering the low recurrence rate, clinical observation is an acceptable management option in patients with compromised margins, especially in elderly and frail patient populations.

Indexed as

Basal Cell CarcinomaHead and Neck NeoplasmsMargins of ExcisionNeoplasm Recurrence, LocalSkin NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesBasal cell carcinomaHead and neck cancerNon-melanoma skin cancerRecurrenceSurgical margins

Identifiers

PMID39979627
PMCPMC12122600

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.