Evidence map›Paper›PMID 39979578›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

Pain profiles and opioid consumption following joint replacement surgery: a prospective observational cohort study.

Rachel Chin, Sarah Tierney, Sanjho Srikandarajah, Yasmine Hoydonckx, Abeer Alomari, Danielle Alvares, Vincent Chan, Anuj Bhatia

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Higher Perioperative Opioid Use Is Associated With Reduced Early Ambulation Following Total Hip and Knee Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel ChinQueen's University, Kingston, ON, Canada.
Sarah TierneyDepartment of Anesthesiology and Pain Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada.
Sanjho SrikandarajahDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Yasmine HoydonckxDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Abeer AlomariDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Danielle AlvaresDepartment of Anesthesia and Pain Management, Toronto Western Hospital, Toronto, ON, Canada.
Vincent ChanDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Anuj BhatiaDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. Anuj.Bhatia@uhn.ca.ORCID 0000-0001-6292-8654

Funding

Research Support, Non-US Gov’t
6 · The paper itself

Abstract

purposeWe sought to analyze postoperative discharge opioid prescription, consumption, and pain over three months following total hip arthroplasty (THA) and total knee arthroplasty (TKA).

methodsWe conducted a prospective observational study in patients undergoing THA and TKA at two centres in Toronto, ON, Canada. We contacted study participants at two, six, and 12 weeks after discharge to collect data on analgesic satisfaction, pain relief, time point of stopping opioids, quantity of unconsumed opioid pills, quality of pain, and mental health. We also evaluated patient factors that may have contributed to a higher opioid consumption or dissatisfaction with the analgesic prescription at six weeks.

resultsThe median [interquartile range] opioid pill count prescribed at the time of discharge for the 443 participants was 60 [50-80]. At 12 weeks after surgery, 33.9% of participants had more than one-third of their prescribed quantity remaining. Three-quarters of the cohort indicated that pain relief after arthroplasty was appropriate at all postoperative follow-ups. The incidence of neuropathic pain reduced from 24.1% before TKA or THA to 4.3% at 12 weeks after arthroplasty. Female sex (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.08 to 2.95; P = 0.03), a history of preoperative opioid use (OR, 2.46; 95% CI, 1.25 to 5.1; P = 0.01), and TKA vs THA (OR, 2.46; 95% CI, 1.47 to 4.17; P = 0.001) were associated with higher opioid consumption at six weeks after arthroplasty.

conclusionA discharge prescription of 60 opioid pills may be excessive for patients undergoing THA or TKA. Identifying patients with risk factors for higher postoperative opioid consumption may result in more appropriate analgesic regimens.

Indexed as

Analgesics, OpioidArthroplasty, Replacement, HipArthroplasty, Replacement, KneePostoperative PainAgedAged, 80 and overCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient SatisfactionProspective StudiesSex FactorsAnalgesics, Opioidjoint replacement surgeryopioid consumptionpain opioid prescriptiontotal hip arthroplastytotal knee arthroplasty

Identifiers

PMID39979578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.