ArticleScientific reports2025
Association of dietary carbohydrate ratio, caloric restriction, and genetic factors with breast cancer risk in a cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Lifelong dietary interventions selectively reverse age-associated circulating microRNA upregulation in a time-dependent manner in female MMTV-TGF-α mice.Biogerontology · 2026Article
- The Role of Mediterranean Diet and Intermittent Fasting in Modulating Inflammation and Clinical Biochemistry Markers in Hereditary Cancer Syndromes: A Review.Current nutrition reports · 2025Review
- Distinct transcriptomic effects of intermittent and chronic caloric restriction in mammary fat pad of a breast cancer mouse model.PloS one · 2025Article
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Authors and funding
10 authors.
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Abstract
The origin of breast cancer (BC) is widely considered to be a result of multiple factors, including both genetic and dietary influences. Dietary patterns shaped by calorie restriction-defined as reduced energy intake without inducing malnutrition, and varying ratios of the three major nutrients are thought to influence tumorigenesis. However, the complex interplay between caloric restriction, carbohydrate intake ratios, and genetic predisposition in influencing BC risk remains inadequately understood. This study aimed to explore these relationships in greater depth. A prospective cohort study which included 139,829 participants aged 40-72 years was conducted. We evaluated the association between dietary carbohydrate ratio under caloric restriction and the BC risk in a genetic risk group by using Cox proportional hazards regression models. The analysis also included a calculation of polygenic risk score (PRS) based on 304 breast cancer-associated genetic loci. A high dietary carbohydrate ratio pattern under caloric restriction was significantly associated with a 21% reduction in BC risk, respectively (HR
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