Evidence map›Paper›PMID 39979526›Full record

ReviewApoptosis : an international journal on programmed cell death2025

A deadly taste: linking bitter taste receptors and apoptosis.

Zoey A Miller, Ryan M Carey, Robert J Lee

Abstract readReview
In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Identification of Bitter Peptides inFoods (Basel, Switzerland) · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zoey A MillerDepartment of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.ORCID 0000-0002-1955-4033
Ryan M CareyDepartment of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.ORCID 0000-0002-0186-2265
Robert J LeeDepartment of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. rjl@pennmedicine.upenn.edu.ORCID 0000-0001-5826-6686

Funding

Immune function of bitter taste receptors in human macrophagesR01AI167971 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Nithin Adappa, Robert J. Lee · 2022 to 2026
$2.5M
Intracellular signaling in airway solitary chemosensory (tuft) cellsR01HL168060 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Robert J. Lee · 2024 to 2026
$1.4M
National Institute of Allergy and Infectious Diseases AI167971NHLBI NIH HHS HL168060NHLBI NIH HHS R01 HL168060NIAID NIH HHS R01 AI167971
6 · The paper itself

Abstract

Humans can perceive five canonical tastes: salty, sour, umami, sweet, and bitter. These tastes are transmitted through the activation of ion channels and receptors. Bitter taste receptors (Taste Family 2 Receptors; T2Rs) are a sub-family of 25 G-protein coupled receptor (GPCR) isoforms that were first identified in type II taste bud cells. T2Rs are activated by a broad array of bitter agonists, which cause an increase in intracellular calcium (Ca

Indexed as

ApoptosisReceptors, G-Protein-CoupledTasteAnimalsCalciumHumansTaste BudsTaste Receptors, Type 2CalciumReceptors, G-Protein-CoupledTaste Receptors, Type 2CalciumCell deathExtraoral taste receptorsMitochondriaPhytochemicalsTaste family 2 receptors

Identifiers

PMID39979526
PMCPMC11946974

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.