Evidence map›Paper›PMID 39979484›Full record

ArticleScientific reports2025

The relationship between body mass index and pathological complete response in Brazilian breast cancer patients.

Fernanda Grace Bauk Richter, André Mattar, Marcelo Antonini, Marina Diógenes Teixeira, Andressa Gonçalves Amorim, Eduardo Camargo Millen, Fabricio Palermo Brenelli, Francisco Pimentel Cavalcante, Felipe Zerwes, Antonio Luiz Frasson and 3 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fernanda Grace Bauk RichterHospital do Pérola Byington, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-3304-1231
André MattarHospital da Mulher, Av Rio Branco 1080, São Paulo, 01206-001, Brazil. mattar.andre@gmail.com.ORCID http://orcid.org/0000-0001-5973-623X
Marcelo AntoniniHospital do Servidor Público Estadual, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1996-7428
Marina Diógenes TeixeiraHospital da Mulher, Av Rio Branco 1080, São Paulo, 01206-001, Brazil.ORCID http://orcid.org/0009-0001-7516-0215
Andressa Gonçalves AmorimHospital da Mulher, Av Rio Branco 1080, São Paulo, 01206-001, Brazil.ORCID http://orcid.org/0000-0002-3077-5873
Eduardo Camargo MillenAmericas Oncologia, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-2113-6324
Fabricio Palermo BrenelliUniversidade Estadual de Campinas, Campinas, Brazil.ORCID http://orcid.org/0000-0003-0589-1423
Francisco Pimentel CavalcanteHospital Geral de Fortaleza, Fortaleza, Brazil.ORCID http://orcid.org/0000-0002-7156-2890
Felipe ZerwesPontifícia Universidade Católica-RS, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0002-1643-727X
Antonio Luiz FrassonHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-1860-6898
Reginaldo Guedes Coelho LopesHospital do Servidor Público Estadual, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7735-8698
Luiz Henrique GebrimHospital Beneficência Portuguesa, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9941-9191
Juliana Monte RealHospital do Servidor Público Estadual, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0970-1519

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Body mass index (BMI) is a key factor in the progression of breast cancer (BC), with conflicting evidence on its influence on pathological complete response (pCR) following neoadjuvant chemotherapy (NAC). Despite these global findings, studies focusing on real-world Brazilian data remain scarce. This study aimed to evaluate the impact of BMI on pCR rates, recurrence-free survival (RFS), and overall survival (OS) in Brazilian women with BC treated with NAC. A retrospective cohort of 1,751 patients with stage I-III invasive primary BC treated between January 2011 and December 2020 at two public healthcare centers Hospital Pérola Byington (HPB) and Hospital do Servidor Público Estadual (HSPE) in Brazil was analyzed. Data included BMI categories (normal, overweight, and obese) and their associations with pCR, RFS, and OS outcomes. Obesity was prevalent (35.5%) among the cohort, with most patients being postmenopausal (50.9%). Tumors were predominantly stage III invasive ductal carcinoma, with triple-negative and luminal B subtypes being the most common. Radical surgery was performed in 79.8% of cases, achieving a pCR rate of 22.3%, and 30.9% of patients experienced recurrence, predominantly systemic (27.7%). No significant differences in pCR, RFS, or OS were observed across BMI categories. BMI was not associated with pCR, RFS, or OS in this large Brazilian cohort, highlighting the need for further studies to explore BMI dynamics during treatment and its potential influence on therapeutic outcomes. Future investigations in diverse healthcare settings may provide additional insights into optimizing breast cancer management across BMI strata.

Indexed as

Body Mass IndexBreast NeoplasmsAdultAgedBrazilFemaleHumansMiddle AgedNeoadjuvant TherapyNeoplasm StagingObesityRetrospective StudiesBody mass indexBreast cancerNeoadjuvant chemotherapyPathological complete responseSurvival analysis

Identifiers

PMID39979484
PMCPMC11842549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.