Evidence map›Paper›PMID 39979480›Full record

ArticleCell biology and toxicology2025

Trps1 regulates mouse zygotic genome activation and preimplantation embryo development via the PDE4D/AKT/CREB signaling pathway.

Xia Jiang, Weiwei Xu, Jiandong Sun, Jianmin Lin, Zihang Lin, Xiuli Lian, Shumin Liao, Shanshan Luo, Yue Liu, Shie Wang

Abstract read
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Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xia Jiang *Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Weiwei Xu *Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Jiandong Sun *Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Jianmin LinKey Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Zihang LinKey Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Xiuli LianKey Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Shumin LiaoKey Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Shanshan LuoKey Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Yue LiuKey Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China. 331042317@qq.com.
Shie WangKey Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, 350122, People's Republic of China. shiewang@fjmu.edu.cn.

Funding

Fujian Province financial special plan project 22SCZZX017National Natural Science Foundation of China 82301881Science and Technology Innovation Foundation of Fujian Province 2023Y9003
6 · The paper itself

Abstract

Despite zygotic genome activation (ZGA) is crucial for early embryonic development, its regulatory mechanism is still unclear in mammals. In the present study, we demonstrate that TRPS1, a maternal factor, plays an essential role in mouse early embryogenesis by regulating the transition from 2-cell to 4-cell embryos during preimplantation development. The absence of Trps1 could leads to impaired ZGA through AKT/CREB signaling pathway. Furthermore, our findings suggest that TRPS1 may modulate the transcription of Pde4d to influence AKT and CREB phosphorylation. Interestingly, compared to Trps1 knockdown alone, co-injection of Trps1 siRNA and Pde4d mRNA significantly enhances the development rate of 4-cell embryos. Collectively, these results indicate a negative involvement of Trps1 in mouse preimplantation embryo development by targeting the PDE4D/AKT/CREB pathway to regulate ZGA.

Indexed as

Cyclic AMP Response Element-Binding ProteinCyclic Nucleotide Phosphodiesterases, Type 4Embryonic DevelopmentProto-Oncogene Proteins c-aktRepressor ProteinsZygoteAnimalsFemaleGene Expression Regulation, DevelopmentalGenomeMicePhosphorylationRNA, Small InterferingSignal TransductionCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinCyclic Nucleotide Phosphodiesterases, Type 4PDE4D protein, mouseProto-Oncogene Proteins c-aktRepressor ProteinsRNA, Small InterferingAKT/CREB pathwayPhosphodiesterase 4dTricho-rhino-phalangeal syndrome 1Zygotic genome activation

Identifiers

PMID39979480
PMCPMC11842480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.