ArticleMicrosystems & nanoengineering2025
Design and developing a robot-assisted cell batch microinjection system for zebrafish embryo.
Article in Microsystems & nanoengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Design of an automated cell batch microinjection system based on magnetic tweezers for zebrafish embryos.Microsystems & nanoengineering · 2026Article
- Robotic cell transportation system based on micropipette resistance modeling.Microsystems & nanoengineering · 2026Article
- Zebrafish as a translational platform for investigating multi-organ pharmacological interactions of traditional Chinese medicine.Frontiers in pharmacology · 2026Review
- Precise Control of Micropipette Flow Rate for Fluorescence Imaging in In Vivo Micromanipulation.Sensors (Basel, Switzerland) · 2025Article
- Automation in microinjection for zebrafish pericardial space with image-based motion control and batch agarose microplate.PloS one · 2025Article
- Base editors in zebrafish: a new era for functional genomics and disease modeling.Frontiers in genome editing · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microinjection of Zebrafish embryos is significant to life science and biomedical research. In this article, a novel automated system is developed for cell microinjection. A sophisticated microfluidic chip is designed to transport, hold, and inject cells continuously. For the first time, a microinjector with microforce perception is proposed and integrated within the enclosed microfluidic chip to judge whether cells have been successfully punctured. The deep learning model is employed to detect the yolk center of zebrafish embryos and locate the position of the injection needle within the yolk, which enables enhancing the precision of cell injection. A prototype is fabricated to achieve automatic batch microinjection. Experimental results demonstrated that the injection efficiency is about 20 seconds per cell. Cell puncture success rate and cell survival rate are 100% and 84%, respectively. Compared to manual operation, this proposed system improves cell operation efficiency and cell survival rate. The proposed microinjection system has the potential to greatly reduce the workload of the experimenters and shorten the relevant study period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.