ArticleAJNR. American journal of neuroradiology2025
DSC MR Perfusion at 7T MRI: An Initial Single-Center Study for Validity and Practicability.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Feasibility of Spin- and Gradient-Echo Dynamic Susceptibility Contrast MRI for Microvascular Characterization at 7 Tesla.NMR in biomedicine · 2026Article
- Comparative evaluation of dynamic susceptibility contrast MRI techniques for brain imaging at 3T and 5T magnetic field strengths.Frontiers in human neuroscience · 2026Article
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7 authors.
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Abstract
background and purposeDSC perfusion is an advanced imaging technique routinely used at 1.5T and 3T MRI. However, its utility is not well known in 7T MRI systems. We aim to evaluate if DSC perfusion is a valid and practicable tool at 7T MRI. MATERIALS AND
methodsA successful DSC perfusion was performed in 9 patients with an FDA-approved 7T MRI system (Siemens Terra with 1tx/32rx Nova head coil) in 2023. Half-dose contrast was administered by hand, followed by saline flush. Acquisition was initiated 45 seconds before contrast injection. Voxel size was 1.5 × 1.5 × 1.6 mm
resultsUploading the source images to imaging software took approximately 30 minutes to a few hours. In a few circumstances, large data caused software crashes. Map generation took approximately 10-15 minutes. Susceptibility artifacts varied from mild to moderate in cerebellum, temporal lobes, brainstem, and basal ganglia and none to minimal in the frontal, occipital, and parietal gyri. Map quality was excellent to reasonably good for all cases. The nrCBV, nrCBF, nrMTT, and nrTTP resulted in similar measurements for each anatomic area. Six target lesions were assessed in 2 different patients with well to excellent visualization on fused maps. Three lesions were characterized as tumor progression (1 biopsy-confirmed, 2 unconfirmed), 1 lesion as indeterminant (regressed in follow-up), and 2 lesions as radiation necrosis (1 stable, 1 regressed on follow-up).
conclusionsDespite limitations with postprocessing issues, it is possible to reliably measure nrCBV, nrCBF, nrMTT, and nrTTP values with DSC perfusion by using a clinical 7T MRI system, and qualitatively, excellent or reasonably good fusion maps can be generated with high resolution.
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