Evidence map›Paper›PMID 39978860›Full record

ArticleThe European respiratory journal2025

Heart rate response and cardiovascular risk during obstructive sleep apnoea: an easy biomarker derived from pulse oximetry.

Margaux Blanchard, Théo Imler, Wen-Hsin Hu, Adrien Waeber, Geoffroy Solelhac, José Haba-Rubio, Sandrine Kerbrat, Abdelkebir Sabil, Wojciech Trzepizur, François Goupil and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. A polygenic risk score modifies the cardiovascular risk associated with obstructive sleep apnea.Sleep advances : a journal of the Sleep Research Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Margaux BlanchardInstitut de Recherche en Santé Respiratoire des Pays de la Loire, Beaucouzé, France.
Théo ImlerCenter for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland.
Wen-Hsin HuDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Adrien WaeberCenter for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland.
Geoffroy SolelhacCenter for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-7135-133X
José Haba-RubioCenter for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland.
Sandrine KerbratDamad, Plouzane, France.
Abdelkebir SabilInstitut de Recherche en Santé Respiratoire des Pays de la Loire, Beaucouzé, France.ORCID https://orcid.org/0000-0002-8966-5441
Wojciech TrzepizurDepartment of Respiratory and Sleep Medicine, Angers University Hospital, Angers, France.ORCID https://orcid.org/0000-0003-0426-3273
François GoupilDepartment of Respiratory Diseases, Le Mans General Hospital, Le Mans, France.
Audrey ThomasUnite de Pathologies Respiratoires, Pôle Santé des Olonnes, Olonne sur Mer, France.
Sébastien BaillyInstitut de Recherche en Santé Respiratoire des Pays de la Loire, Beaucouzé, France.ORCID https://orcid.org/0000-0002-2179-4650
Ali AzarbarzinDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Peter VollenweiderDepartment of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-0765-896X
Pedro Marques-VidalDepartment of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-4548-8500
Julien VaucherDepartment of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Raphael HeinzerCenter for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-3215-7788
Frédéric GagnadouxDepartment of Respiratory and Sleep Medicine, Angers University Hospital, Angers, France frgagnadoux@chu-angers.fr.ORCID https://orcid.org/0000-0002-4231-5102

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleep apnoea-specific heart rate response (ΔHR) has been identified as a promising biomarker for stratifying cardiovascular (CV) risk and predicting positive airway pressure (PAP) benefit in obstructive sleep apnoea (OSA). However, the need for prior manual scoring of respiratory events potentially limits the accessibility and reproducibility of ΔHR. We aimed to evaluate the association of pulse rate response to oxygen desaturations automatically derived from pulse oximetry (ΔHR

methodsΔHR

resultsMACEs occurred in 768 patients from PLSC and 87 patients from HypnoLaus (median follow-up 8.0 and 7.5 years, respectively). Multivariable Cox models showed that subjects with high ΔHR

conclusionΔHR

Indexed as

Cardiovascular DiseasesHeart RateOximetrySleep Apnea, ObstructiveAdultAgedBiomarkersCohort StudiesContinuous Positive Airway PressureFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedOxygen SaturationProportional Hazards ModelsBiomarkers

Identifiers

PMID39978860
PMCPMC12056247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.